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A study published the same day in the Journal of Experimental Medicine highlighted the harmful effects of obesity on the long-term health of hematopoietic stem cells, AAAS's technology news-sharing platform EurekAlert!reported Wednesday.
the study led by the Cincinnati Institute of Childhood Cancer and Hematology.
a wealth of data on genetic models of obese mice, obesity can cause lasting and harmful changes in hematopoietic stem cells in the body, including changing their cellular structure and reducing their functional adaptability. "It is now recognized that blood stem cells are made up of many cell subgroups and that maintaining the health and functioning of hematopoietic stem cells is essential for human health," said lead author Dr. Mian Reynolds,
.
", Reynolds said, age factors and environmental pressures can reduce the healthy diversity of hematopoietic stem cells, which may include showing pre-leukemia symptoms.
tests showed that these effects were gradual, and that some harmful manifestations persisted even after the mice's weight was normalized through a controlled diet.
researchers report that, in a mechanism, these changes in the hematopoietic system appear to be related to excessive expression of transcription factors called Gfi1.
Gfi1 is a regulatory gene that tells other genes what to do.
is the oxidative stress caused by obesity, which leads to overexpression.
when this happens, it causes continuous changes in hematopoietic stem cells, followed by molecular confusion.
researchers say their research provides the basis for investigating lifestyles, such as the lasting effects of diet on the blood and the potential for blood cancer.
hematopoietic stem cells are an important tool for treating leukemia and other blood diseases.
the study also raises the risks of using hematopoietic stem cells isolated from obese people during therapeutic transplantation.
researchers explain that little is known about how the level of obesity in bone marrow donors affects the quality of hematopoietic stem cells, and hopes to better understand the molecular changes caused by obesity and predict the potential risks associated with it.
.