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    Home > Biochemistry News > Biotechnology News > The He Yawen team of Shanghai Jiaotong University and relevant researchers from all over the world published a review article on "Intraspecific, Interspecific and Cross-border Signal Exchange Mediated by Group Induction Signal DSF"

    The He Yawen team of Shanghai Jiaotong University and relevant researchers from all over the world published a review article on "Intraspecific, Interspecific and Cross-border Signal Exchange Mediated by Group Induction Signal DSF"

    • Last Update: 2022-09-21
    • Source: Internet
    • Author: User
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    Recently, The International Authoritative Review Journal of Microbiology, Trends in Microbiology, published a review article by Professor He Yawen's team at the School of Life Science and Technology of Shanghai Jiao Tong University" entitled "DSF-family quorum sensing signal-mediated intraspecies, interspecies, and.
    " inter-kingdom communication)”
    。 Prof.
    Yawen He is the first author and corresponding author of the review, Professor Deng Yue of Sun Yat-sen University, Prof.
    Yansong Miao of Nanyang Technological University in Singapore is the co-first author of the review, Professor Tian Jing of Northwestern University and Researcher Subhadeep Chatterjee of the Centre for DNA Fingerprinting & Diagnostics, Steven Lindow, Fellow of the University of California, Berkeley, and Assistant Professor Tuan Minh Tran of the University of South Alabama participated in the writing
    of the review article.

    DSF (Diffusible signaling factor) signaling molecules are a class of medium-chain cisunsaturated fatty acids produced by a variety of Gram-negative bacteria (Figure 1
    ).
    These microorganisms recognize the DSF they synthesize and secrete, sense the cell density of their own population, induce the expression of related genes, and adjust the cell metabolism and physiological state
    accordingly.
    According to the signal reception and conduction mechanism, DSF-mediated intraspecific AC is mainly divided into three categories: (I) plant pathogen xanthomonas as representative, DSF is received and conducted
    by RpfC/RpfG two-component system 。 Professor He Yawen's team at Shanghai Jiao Tong University has been leading this research field, and has identified the chemical structure, signaling pathway and regulatory biological function of the signaling molecules of the DSF family in Xanthomonas xanthomonas, elucidated the molecular mechanism of the DSF biosynthetic pathway and the DSF turnover, and further discovered the delicate interaction between the host plant immune system and the Xanthomonas DSF group sensing system (Figure 2).

    (II) Animal and plant pathogen Burkhella as a representative, DSF is received and conducted
    by the regulatory protein RpfR.
    The team of Professor Deng Music of Sun Yat-sen University has been leading this research area (Figure 3
    ).
    (III) Represented by conditionally pathogenic Pseudomonas aeruginosa, the reception and conduction mechanism of DSF has yet to be studied
    .

    Fig.
    1 Three DSF-mediated intraspecific AC systems and the signaling molecules on which they depend

    Fig.
    2 DSF biosynthesis and signaling pathway in Wild rape xanthomonas

    Fig.
    3 Burkholderia induction of BDSF signals and their conduction pathways

    DSF-producing bacteria are also able to use DSF signaling to conduct interspecific communication with other bacteria (Figure 4), including Burkholderia spp.
    , Stenotrophomonas maltophilia, Pseudomonas aeruginosa, Francisella novicida, and Bacillus ( Bacillus), Bdellovibrio bacteriovorus, Salmonella, etc
    .
    In the currently published literature, most DSF-producing bacteria use secreted DSF signaling molecules to interfere with the growth or development of other bacteria, limit their development, and maintain their competitiveness
    in the local environment.

    DSF-producing bacteria can also carry out transboundary signal exchanges with eukaryotes (Figure 5
    ).
    DSF family signaling molecules significantly affect candida albicans mycelium development and biofilm formation, affecting their pathogenicity
    .
    Professor Steven Lindow's team at the University of California, Berkeley, systematically elucidated the ability of Xyderma bacterium to use DSF signaling molecules to regulate its colonization ability in the foregut of sharp shooter leaf hoppers, which facilitates the transfer of Xyperus causticis to host plant vascular bundles
    such as grapes through this stinging insect 。 Professor Miao Yansong's team at Nanyang Technological University first found that DSF can induce plant cell membrane sterol enrichment, highly induce plant cell wall cellulose synthesis, and affect the biochemical properties of immune function molecules on the cell membrane, such as plant flagellin receptor aggregation and endocytosis, thereby inhibiting the immune response (PTI) excited by molecular patterns related to plant disease history; Further studies have found that DSF affects the biophysical properties of the plant cell wall-plasma membrane-actin cytoskeleton (CW-PM-AC) continuum, disrupting the recognition of protein molecules and the assembly of macromolecules on the surface of the cell membrane, resulting in dysregulation of the plant immune system (Figure 5
    ).
    。 Professor Jing Tian of Northwestern University found that DSF signaling can effectively inhibit the inflammatory response induced by lipopolysaccharides (LPS) in zebrafish, and its mechanism of action may be to interfere with the Toll-like receptor pathway to inhibit the expression of downstream inflammatory factors and affect the activation of the caspase family cascade, inhibiting the expression of lysosomal histase genes and thus alleviating inflammation-induced apoptosis
    .
    Elucidating the intraspecific, interspecific and transboundary communication phenomena and mechanisms mediated by DSF further deepens the connotation of microbial sociology and also contributes to the development of new anti-infective strategies

    Figure 4 DSF-mediated interspecific and transboundary signal exchanges

    Figure 5 Signaling pathways of DSF in Arabidopsis thaliana and zebrafish

    This research was funded
    by the National Key R&D Program, the National Natural Science Foundation of China and Shanghai Nongle Biological Products Co.
    , Ltd.
    Thank you professor Lian-Hui Zhang for his guidance, support and encouragement
    .

    Thesis link:

    Faculty of Life Sciences and Technology
    Faculty of Life Sciences and Technology
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