The Hepatology study found that people who have gone to college and exercise more have a lower prevalence of non-alcoholic fatty liver disease

Editor’s note iNature is China’s largest academic official account.
It is jointly created by the doctoral team of Tsinghua University, Harvard University, Chinese Academy of Sciences and other units.
The iNature Talent Official Account is now launched, focusing on talent recruitment, academic progress, scientific research information, interested parties can Long press or scan the QR code below to follow us
.

The influence of iNature diet quality (DQ), physical activity (PA) and socioeconomic status (SES) on the risk of non-alcoholic fatty liver disease (NAFLD) is unclear
.

The study examined the association between DQ, PA, SES, and NAFLD risk
.

On October 20, 2021, Indiana University’s Naga Chalasani team published a research paper titled "High quality diet, physical activity and college education are associated with low risk of NAFLD among the US population" online in Hepatology.
A cross-sectional analysis of the National Health and Nutrition Examination Survey in the United States in 2016 included 3589 participants who provided reliable information on vibration-controlled transient elastography (VCTE) measurements, 24-hour diet recall, PA and SES
.

DQ is assessed by the Healthy Eating Index (HEI)-2015
.

PA is determined by the Global Sports Activity Questionnaire
.

SES is evaluated by education level and household poverty income ratio (PIR)
.

The risk of NAFLD is considered by using the composite results measured by VCTE: non-NAFLD and NAFLD without clinically significant fibrosis (CSF) and NAFLD with CSF
.

Compared with inactive participants (<600 MET minutes/week), NAFLD risk of physically active (≥600 MET minutes/week) is lower (OR: 0.
71, P=0.
043); compared with non-HQD, high quality Diet (HQD) (HEI>56.
64) was associated with a lower risk of NAFLD (OR: 0.
58, P<0.
01)
.

Physically active HQD had the lowest NAFLD risk (OR: 0.
43, P<0.
01)
.

Body mass index (BMI) and waist circumference (WC) significantly mediate the effects of DQ and PA on the risk of NAFLD
.

Education (university or above) (OR: 0.
65, P=0.
034), but not related to PIR, but related to a reduced risk of NAFLD
.

HQD and increased PA partially mediate the impact of education on NAFLD risk
.

The total impact of education on DQ-mediated NAFLD risk was 29%, and PA was 8%
.

In summary, the study found that high-quality diet, increased physical activity, and college education are associated with a lower risk of NAFLD in the American population
.

In the United States, approximately one-third of adults suffer from non-alcoholic fatty liver disease (NAFLD), and with the prevalence of obesity and type 2 diabetes (T2DM), the prevalence continues to increase
.

Unhealthy life>
.

Life>
.

In recent years, several diet scores have been developed to explore the association between diet quality (DQ) and health outcomes
.

A healthier DQ based on different diet scores (Diet Methods to Stop High Blood Pressure, Alternative Mediterranean Diet Score, and Alternative Healthy Diet Index-2010) has been shown to reduce all-cause mortality, cardiovascular disease, cancer, and T2DM, respectively.
22%, 22%, 15% and 22%
.

In addition to dietary recommendations, the US Physical Activity Guidelines recommend that adults do at least 150 minutes of moderate-intensity aerobic exercise or 75 minutes of vigorous exercise per week, or an equivalent combination, because it is associated with positive health outcomes
.

It has been proven that increasing PA is not only related to a reduction in the risk of NAFLD, but also to a reduction in all-cause mortality and cardiovascular mortality in individuals with NAFLD in the US population
.

Socio-economic differences in nutrition and physical activity are well documented, which explains some of the observed social inequalities in health
.

People with higher socioeconomic status (SES) tend to be more physically active and have healthier eating habits, thus helping to improve their health
.

Therefore, it is necessary to evaluate the relationship between DQ, PA and SES in the context of NAFLD risk
.

The influence of diet quality (DQ), physical activity (PA), and socioeconomic status (SES) on the risk of non-alcoholic fatty liver disease (NAFLD) is unclear
.

The study’s cross-sectional analysis of the 2017-2018 National Health and Nutrition Examination Survey in the United States included 3589 participants who provided information on vibration-controlled transient elastography (VCTE) measurements, 24-hour diet recall, PA and SES Reliable information
.

DQ is assessed by the Healthy Eating Index (HEI)-2015
.

PA is determined by the Global Sports Activity Questionnaire
.

SES is assessed by education level and household poverty income ratio (PIR)
.

The risk of NAFLD is considered by using the composite results measured by VCTE: non-NAFLD and NAFLD without clinically significant fibrosis (CSF) and NAFLD with CSF
.

Compared with inactive participants (<600 MET minutes/week), NAFLD risk of physically active (≥600 MET minutes/week) is lower (OR: 0.
71, P=0.
043); compared with non-HQD, high quality Diet (HQD) (HEI>56.
64) was associated with a lower risk of NAFLD (OR: 0.
58, P<0.
01)
.

Physically active HQD had the lowest NAFLD risk (OR: 0.
43, P<0.
01)
.

Body mass index (BMI) and waist circumference (WC) significantly mediate the effects of DQ and PA on the risk of NAFLD
.

Education (university or above) (OR: 0.
65, P=0.
034), but it has nothing to do with PIR, but it is related to NAFLD risk reduction
.

HQD and increased PA partially mediate the impact of education on NAFLD risk
.

The total impact of education on DQ-mediated NAFLD risk was 29%, and PA was 8%
.

In summary, the study found that high-quality diet, increased physical activity, and college education are associated with a lower risk of NAFLD in the American population
.

Reference message: https://aasldpubs.
onlinelibrary.
wiley.
com/doi/10.
1002/hep.
32207