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Innovation: Hong Kong Polytechnic University's Yang Mo team designed a multifunctional nanodroplet loaded with lactate oxidase to achieve the dual consumption of lactic acid/ATP in the tumor and the generation of oxygen free radicals, thereby regulating the tumor microenvironment (TME).
Cancer treatment
.
The nanosystem finally achieves the elimination of tumors in situ and the inhibition of tumor metastasis through the coordinated treatment of cascade metabolism-chemical kinetics
.
Keywords: Adenosine Triphosphate (ATP), Lactic Acid, Double Consumption, Tumor Metabolism, Cooperative Therapy Regulating Tumor Microenvironment (TME) is considered to be an emerging and effective cancer treatment strategy
.
Recently, researchers have discovered that a major feature of TME is that tumor cells produce a large amount of intratumoral lactic acid accumulation through glycolysis, which plays an important role in promoting tumor development
.
The accumulation of lactic acid leads to tumor angiogenesis, metastasis and immunosuppression, and promotes tumor growth and invasion
.
Therefore, lactic acid was initially regarded as an effective therapeutic target, and the abnormal metabolism of TME was regulated by blocking its production or direct consumption, and finally reached the effect of tumor treatment
.
However, lactic acid inhibition methods such as enzyme-catalyzed reactions require the supply of oxygen and are therefore limited by the hypoxic environment inside the tumor
.
Even if hydrogen peroxide (H2O2), which has a certain killing effect on tumor cells, is produced in the process of lactic acid inhibition, its effect is still not enough to achieve effective inhibition of tumor cell growth
.
In addition, adenosine triphosphate (ATP) is another major biochemical component in the tumor microenvironment, which provides energy for the survival and proliferation of tumor cells
.
Therefore, ATP depletion is considered a promising method to inhibit tumor growth
.
Current cancer treatment strategies that regulate the tumor microenvironment are often based on regulating only one component
.
In response to this problem, the Hong Kong Polytechnic University's Yang Mo team designed a perfluorocarbon (PFOB) coated with a tannic acid-iron (TA-Fe(III)) complex by loading lactate oxidase (LOX).
Nano-droplets (PTFL NPs) of nano-medicine can realize efficient tumor cascade metabolism-chemodynamic therapy
.
The nanomedicine can eliminate the tumor in situ and inhibit tumor metastasis through the double consumption of lactic acid and ATP in the tumor and the generation of free radicals.
The relevant results are published in Advanced Science
.
In this work, the coated perfluorocarbon nano-droplets first carried oxygen to the hypoxic area of the tumor and then released it to promote the consumption of lactic acid and the production of H2O2 by the loaded LOX catalyzed
.
The consumption of lactic acid regulates the abnormal metabolism of tumors, down-regulates the expression of vascular endothelial growth factor (VEGF), and ultimately inhibits angiogenesis and tumor metastasis
.
At the same time, the TA-Fe(III) complex depletes the nutrient source ATP in the cell to inhibit tumor growth
.
Finally, the Fe(III) ions released during the ATP consumption process are further reduced by TA to Fe(II) ions, and the H2O2 generated during the lactic acid consumption process is catalyzed into cytotoxic •OH oxygen free radicals, which further affects tumor cells.
Kill
.
In addition, the photoacoustic (PA) imaging contrast provided by the TA-Fe(III) complex further improves the overall treatment accuracy and efficacy
.
Experimental results show that the nanosystem can effectively inhibit tumor growth and invasion through cascade metabolism-chemical kinetics coordinated therapy, which will provide new ideas for tumor treatment by targeting abnormal metabolism in the tumor microenvironment.
.
Tian Feng, a postdoctoral fellow from the Department of Biomedical Engineering, Hong Kong Polytechnic University, is the first author, and the corresponding author is Professor Yang Mo from the Department of Biomedical Engineering, Hong Kong Polytechnic University
.
WILEY paper information: Dual-Depletion of Intratumoral Lactate and ATP with Radicals Generation for Cascade Metabolic-Chemodynamic TherapyFeng Tian, Shiyao Wang, Keda Shi, Xingjian Zhong, Yutian Gu, Yadi Fan, Yu Zhang, Mo Yang*Advanced ScienceDOI: 10.
1002/advs .
202102595 Click "Read Original" in the lower left corner to view the original text of the paper
.
Introduction to AdvancedScience Journal "Advanced Science" (Advanced Science) Wiley is a high-quality open source journal founded in 2014.
It publishes innovative achievements and cutting-edge progress in various fields such as materials science, physical chemistry, biomedicine, and engineering
.
The journal is dedicated to disseminating scientific research results to the public to the greatest extent, and all articles are freely available
.
The latest impact factor is 16.
806, and the 2020 SCI journals of the Chinese Academy of Sciences will be divided into the Q1 area of the material science category and the Q1 area of the engineering technology category
.
Press and hold the QR code on the official WeChat platform of AdvancedScienceNewsWiley's scientific research information.
Follow us to share cutting-edge information｜Focus on scientific research trends to publish scientific research news or apply for information sharing, please contact: ASNChina@Wiley.
com
Cancer treatment
.
The nanosystem finally achieves the elimination of tumors in situ and the inhibition of tumor metastasis through the coordinated treatment of cascade metabolism-chemical kinetics
.
Keywords: Adenosine Triphosphate (ATP), Lactic Acid, Double Consumption, Tumor Metabolism, Cooperative Therapy Regulating Tumor Microenvironment (TME) is considered to be an emerging and effective cancer treatment strategy
.
Recently, researchers have discovered that a major feature of TME is that tumor cells produce a large amount of intratumoral lactic acid accumulation through glycolysis, which plays an important role in promoting tumor development
.
The accumulation of lactic acid leads to tumor angiogenesis, metastasis and immunosuppression, and promotes tumor growth and invasion
.
Therefore, lactic acid was initially regarded as an effective therapeutic target, and the abnormal metabolism of TME was regulated by blocking its production or direct consumption, and finally reached the effect of tumor treatment
.
However, lactic acid inhibition methods such as enzyme-catalyzed reactions require the supply of oxygen and are therefore limited by the hypoxic environment inside the tumor
.
Even if hydrogen peroxide (H2O2), which has a certain killing effect on tumor cells, is produced in the process of lactic acid inhibition, its effect is still not enough to achieve effective inhibition of tumor cell growth
.
In addition, adenosine triphosphate (ATP) is another major biochemical component in the tumor microenvironment, which provides energy for the survival and proliferation of tumor cells
.
Therefore, ATP depletion is considered a promising method to inhibit tumor growth
.
Current cancer treatment strategies that regulate the tumor microenvironment are often based on regulating only one component
.
In response to this problem, the Hong Kong Polytechnic University's Yang Mo team designed a perfluorocarbon (PFOB) coated with a tannic acid-iron (TA-Fe(III)) complex by loading lactate oxidase (LOX).
Nano-droplets (PTFL NPs) of nano-medicine can realize efficient tumor cascade metabolism-chemodynamic therapy
.
The nanomedicine can eliminate the tumor in situ and inhibit tumor metastasis through the double consumption of lactic acid and ATP in the tumor and the generation of free radicals.
The relevant results are published in Advanced Science
.
In this work, the coated perfluorocarbon nano-droplets first carried oxygen to the hypoxic area of the tumor and then released it to promote the consumption of lactic acid and the production of H2O2 by the loaded LOX catalyzed
.
The consumption of lactic acid regulates the abnormal metabolism of tumors, down-regulates the expression of vascular endothelial growth factor (VEGF), and ultimately inhibits angiogenesis and tumor metastasis
.
At the same time, the TA-Fe(III) complex depletes the nutrient source ATP in the cell to inhibit tumor growth
.
Finally, the Fe(III) ions released during the ATP consumption process are further reduced by TA to Fe(II) ions, and the H2O2 generated during the lactic acid consumption process is catalyzed into cytotoxic •OH oxygen free radicals, which further affects tumor cells.
Kill
.
In addition, the photoacoustic (PA) imaging contrast provided by the TA-Fe(III) complex further improves the overall treatment accuracy and efficacy
.
Experimental results show that the nanosystem can effectively inhibit tumor growth and invasion through cascade metabolism-chemical kinetics coordinated therapy, which will provide new ideas for tumor treatment by targeting abnormal metabolism in the tumor microenvironment.
.
Tian Feng, a postdoctoral fellow from the Department of Biomedical Engineering, Hong Kong Polytechnic University, is the first author, and the corresponding author is Professor Yang Mo from the Department of Biomedical Engineering, Hong Kong Polytechnic University
.
WILEY paper information: Dual-Depletion of Intratumoral Lactate and ATP with Radicals Generation for Cascade Metabolic-Chemodynamic TherapyFeng Tian, Shiyao Wang, Keda Shi, Xingjian Zhong, Yutian Gu, Yadi Fan, Yu Zhang, Mo Yang*Advanced ScienceDOI: 10.
1002/advs .
202102595 Click "Read Original" in the lower left corner to view the original text of the paper
.
Introduction to AdvancedScience Journal "Advanced Science" (Advanced Science) Wiley is a high-quality open source journal founded in 2014.
It publishes innovative achievements and cutting-edge progress in various fields such as materials science, physical chemistry, biomedicine, and engineering
.
The journal is dedicated to disseminating scientific research results to the public to the greatest extent, and all articles are freely available
.
The latest impact factor is 16.
806, and the 2020 SCI journals of the Chinese Academy of Sciences will be divided into the Q1 area of the material science category and the Q1 area of the engineering technology category
.
Press and hold the QR code on the official WeChat platform of AdvancedScienceNewsWiley's scientific research information.
Follow us to share cutting-edge information｜Focus on scientific research trends to publish scientific research news or apply for information sharing, please contact: ASNChina@Wiley.
com
