The human front buckle brings back transcriptional map analysis of spindle-shaped neurons.

Cognitive functions of the human brain, such as language, thinking, and emotion, give the human mind, wisdom and creativity.
study found that a new class of nerve cells, called von Economo neuron (VEN), or spindle (spindle neuron neurons) have evolved in the brains of primates such as old-world monkeys, apes and humans, but are not found in more primitive primates such as new continent monkeys.
the largest number of ENs in the human brain, but only concentrated in the forebrain and the front button to bring back two brain regions.
given the morphology and distribution characteristics of VEN's huge bipolar neurons, neurobiologists speculate that VEN may be involved in advanced cognitive functions such as human cognitive abilities.
Because of the limited distribution of VEN in the brain and technical limitations, the exact function of VEN is almost unknown, and the construction of the transcription map of such cells is an important basic work to understand the function of cells.
, the Kunming Institute of Zoology of the Chinese Academy of Sciences, in collaboration with the Chinese Brain Bank Center of Zhongnan National University, used laser micro-cutting and microsample RNA sequencing techniques to analyze the transcription map from the spindle-shaped neurons brought back from the human front buckle, and found more than 300 genes in which the specific expression of spindle neurons increased or decreased, and identified four new hammer-shaped neuronal markers. Further analysis of transcription group data
found that these genes are closely related to the morphological development of spindle-shaped neurons (e.g. dendritic branching and myelinization) and functions (such as human human emotional diseases).
the analysis of human spindle neuron transcription maps provides important basic data for understanding such types of neurons that may play an important role in primate brain evolution and the origin of the human brain, as well as important information for studying the pathogenesis of human neuropsychiatric disorders, such as autism.
published the research in cerebral Cortex, Kunming Animal Institute Ph.D. Yang Lixin, Ph.D. students Yang Yandong, Yuan Jiamei as co-first author of the article, Kunming Animal Institute researcher Yu Bing as the article's communication author.
the project was supported by the Chinese Academy of Sciences' leading special (Class B) "Evolutionary Analysis and Regulation of Animal Complexity" and the key projects of the National Natural Science Foundation of China.
Source: Kunming Animal Research Institute.