Influenza B virus is one of the most important pathogens causing seasonal influenza.
statistics show that seasonal influenza kills 300,000 to 600,000 people worldwide each year, and seasonal influenza cases caused by influenza B can account for more than half of all cases.
, the complications caused by influenza B infection in children and the elderly are more serious than those of influenza A virus, and the number of fatal cases from onset to death is shorter than influenza A.
the basic research on influenza B virus is far less than that of influenza B, and there are many problems about influenza B, including the interaction with the host, the pathogenesis of disease and the host immune defense mechanism.
Liu Wenjun of the Institute of Microbiology of the Chinese Academy of Sciences used high-throughput sequencing technology to determine the transcription group of human lung cell line A549 infected with influenza B virus, and systematically studied the host transcription response of the cell line to influenza B infection.
through gene annotation analysis, transcription factor target analysis, interferon group analysis, KEGG signal path analysis found that type III interferon (including IFN-1, s3, and s4) instead of type I interferon (IFN-alpha/beta) dominated by natural immune signal cascades and extensive antiviral gene expression is a significant feature of the host transcription response.
research published in Protein and Cell.
Bunia virus is a large class of negative-duty segmented RNA viruses, which is one of the largest groups of RNA viruses.
The International Virus Naming Council (ICTV) upgraded the original Bunia virus section to bunia virus in 2016 due to the continued discovery of the new Bunia virus, which consists of nine sections.
some Bunia viruses are carriers of arthropods that can cause deadly human diseases such as Congolese haemorrhagic fever, Rift Valley fever and tick worm disease, which has been prevalent in our country in recent years.
Liu Wenjun's team studied the atomic structure, interaction mode and functional mechanism of the components of the RNAprotein complex (RNP) of the nine sections of the Bunia virus, and on this basis, put forward a model of the N protein and L protein in THE RNP to coordinate the transcription of the viral genome.
related research published in the journal Critical Reviews in Microbiology. Dr.
Sun Yeping is the first author of the related paper, and associate researcher Li Jing and researcher Liu Wenjun are the authors of the newsletter.
research has been supported by the National Natural Science Foundation of China, the Chinese Academy of Sciences key deployment projects and the national key research and development programs.