The idea of implementing chromosome "16 in 1" came up with the idea of walking.

On November 4th, at the 2018 Tencent WE Conference, Chinese scientistyud with the chromosome "16 in 1" shared with us that the research idea had been come up with during a walk.
August 2, 2018, nature, a leading international academic journal, published two scientific findings of the same "choice" in a rare article: one from the synthetic field "old man", a member of the American Academy of Sciences, professor of the New York University School of Medicine, Jef D. Boeke team;
the experiments and analyses mentioned in the two results have their own twists and turns, but from the results, the former only achieves "16 in 2" and the latter makes "16 in 1".
this time, China took the lead. On November 4th,
, at the 2018 Tencent WE Conference, We told the story behind this lead: Everything starts with the inspiration of the day of May 8th, 2013.
1995-2001, Professor Stanley N. Cohen, one of the founders of genetic engineering, was a student at Stanford University in the United States.
at that time the classical genetic engineering has been very mature, like to think of the heavy army began a beautiful dream - with genomic engineering technology to achieve artificial life.
as Chinese scientists continue to make landmark achievements in the life sciences, including synthetic proteins, tRNAs, and chromosomal DNA, the "dream" of artificial life doesn't seem out of reach.
we know that pronuclear organisms have 1 chromosome, and chromosome configuration is ring type, eyrebiotics have multiple chromosomes, and chromosome configuration is a line type. Whether
can break the boundaries of natural life is a question that the heavy army keeps thinking about while walking.
May 8, 2013, a walking juniper suddenly thought that it might be possible to make it through brewing yeast.
"The number of chromosomes in humans, animals, plants, yeasts and other eukaryotic organisms is numerous but 'random', and yeast can assemble all genetic material on one chromosome like pronuclear organisms."
," yu explained.
at this point, although the material has been determined, but in the end can it be artificial single-chromosome eukaryotic organisms with normal function? The heavy army is not sure, because there is a technical bottleneck that needs to be broken - chromosomal fusion should try to avoid affecting gene expression and cell growth, knock out the near-telomere repeat sequence, chromosome position sequence can be random, the position of the silk particlecenter center.
How to realize multi-point simultaneous cutting and efficient homologous reorganization is a difficult problem in front of the heavy army.
coincides with the year's gene editing technology (CRISPR/Cas9) "out of the sky", the heavens and earth and the heavy military team with the spirit of artisans, step by step, the chromosomes two precise fusion and strict verification, and ultimately success.
specifically, this study by the research team has established a series of strains with 16 chromosomes continuous fusion, subverted the traditional concept of chromosomal three-dimensional structure to determine gene expression, and has important value for chromosomal evolution, chromosomal replication, telomere biology, silk particle biology, subtractive division and the relationship between cytonuclear structure and function, and provides new materials and new ideas for yeast genetics research.
, compared with the 32 telomeres of natural brewery yeast, the single-line chromosome synrated by the Team of The Heavy Army artificially has only 2 telomeres, providing a good model for the study of human telomere function and cell aging.
said humorously that the origin of the story is a bold guess, but the guess is followed by the determination of the principles of rational design, coupled with the coordination of core technology, and "engineering" accurate implementation.
four elements are indispensable, because one step is wrong, the whole "building" will collapse.
the world is really wonderful, the synthetic field "old man", the American Academy of Sciences, New York University School of Medicine professor Jef Boeke team to study wine yeast for more than 40 years, but failed to complete a chromosome fusion, the result of a "outsider" to seize the opportunity, the chinese smile said he was lucky.
in fact, looking at the 2,000-page manuscript son of the Army from 2013 to 2018 for scientific thinking, experimental design, etc., we know that any success is never a one-off, and scientific research is even more.
regard editing Newton and Einstein as their idols, and posted their portraits in the office to remind themselves to learn from the "great man" of the heavy army encourages everyone to be brave to explore.
he said that great men need to have famous quotes, he also learned to organize a line: "by the imagination to open a door to the future, by rational choice of one of the right ones."
" Source: Biological Exploration.