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Apoptosis is an important means to maintain the dynamic balance of cell numbers, and abnormal apoptosis will lead to the occurrence of many diseases
Ouyang Bo's team analyzed the precise three-dimensional structure of Bax's core domain α2-α5 complex in the lipid bilayer membrane system for the first time through nuclear magnetic resonance technology, and found that α4 and α5 formed a flat hydrophobic plane
Based on this NMR structure, Lin Jialing’s team prepared R89E, F93E, F114E, A117D, and S118D mutations to disrupt the electrostatic or hydrophobic interaction between Bax and the membrane, and used liposome fluorescent pigment release experiments to test whether Bax can still function.
Ph.
Article link: https://
The top view of the model of Bax (α2-α5) forming holes in the outer mitochondrial membrane (left) and the enlarged view of the side attached to the lipid bilayer membrane (right)