The incidence of type 1 diabetes in China may be underestimated. Professor Yang Jinkui’s team publishes the latest flow research

Yimaitong compiles and organizes, please do not reprint without authorization
.

Introduction: Recently, a research on the flow regulation of type 1 diabetes in China (a population-based registration study) was published in the journal Diabetes Care.
This flow research study by Professor Yang Jinkui’s team from Beijing Tongren Hospital affiliated to Capital Medical University further revealed that China’s type 1 diabetes The true incidence of diabetes (T1D)
.

Regarding type 1 diabetes, the results of the flow regulation tell us the fact that the incidence of type 1 diabetes in China may be underestimated
.

 The researchers used the T1D registration data from the Beijing Municipal Health Commission Information Center (BMHCIC) to investigate the incidence of T1D in all age groups (0-100 years) from 2007 to 2017, including data from 21.
7 million people
.

Estimate the incidence trend by evaluating the annual percentage change (APC) and average annual percentage change (AAPC) of T1D, and predict the number of new cases of T1D in the next 10 years
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 The main results column ➤The incidence of T1D increased significantly from 2.
72 per 100,000 people in 2007 to 3.
60 per 100,000 people in 2017 (P <0.
001)
.

➤The peak incidence of T1D occurs in the age group of 10-14 years
.

➤A significant increase in the incidence of T1D was observed in the age group ≥30 years (from 1.
8 per 100,000 people to 3.
52 per 100,000 people)
.

➤The prevalence of diabetic ketoacidosis at diagnosis is the highest in the 0-4 year old age group
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 China still lacks high-quality type 1 diabetes flow regulation data.
The incidence of type 1 diabetes varies greatly among countries/regions.
Western countries, especially Northern Europe, have a high incidence, and Asian countries including China have a low incidence
.

According to the "World Diabetes (DiaMond)" study, the incidence of T1D among Chinese children from 1985 to 1994 was 0.
51 per 100,000 person-years, which is one of the countries with the lowest incidence in the world
.

The current report shows that in the past three decades, the incidence of T1D has increased globally, and environmental and behavioral factors have played an important role in the increase in the incidence of T1D in recent decades
.

Although China has experienced rapid economic growth and life>
.

 Latest data: The peak incidence of type 1 diabetes in China is in the 10-14 year-old group.
The study found that the incidence of T1D in this cohort increased from 2.
72 per 100,000 in 2007 to 3.
60 per 100,000 in 2017
.

The incidence of T1D in men increased from 2.
83/100,000 to 3.
64/100,000; in women, it increased from 2.
60/100,000 to 3.
52/100,000, and the ratio of male to female incidence was 1.
130 (P<0.
001)
.

Age and incidence rate: The peak incidence occurred in the 10-14-year-old group, which was significantly higher than other age groups (P<0.
001)
.

After adjusting for the annual population changes from 2007 to 2017, the incidence of T1D was the highest among people aged 10-14, at 7.
15 per 100,000 people, and the lowest among people aged 75 years or older, at 1.
49 per 100,000 people
.

  Gender and morbidity: ➤The incidence rate of men and women in the population less than 30 years old is 0.
885 (P=0.
002); the incidence rate of men and women in the population ≥30 years old is 1.
272 (P<0.
001)
.

Note: The black, blue, and red lines represent the entire population, males, and females, respectively; the shaded area represents the 95% confidence interval based on Poisson distribution.
Figure 1 The incidence of T1D and 95% confidence interval by gender.
The incidence trend of type 1 diabetes in China : Incidence rate in people ≥30 years old has increased rapidly.
From 2007 to 2017, the incidence rate of T1D has been increasing, with an average annual increase of 2.
3% (P<0.
05)
.

 From 2007 to 2017, the incidence of T1D increased significantly among adults, but did not increase significantly among young people: ➤In the age groups of 0-14 and 15-29, the incidence of T1D was basically stable (AAPC was 2.
6% and-respectively) 0.
4%; P>0.
05); ➤The AAPC of the 30-year-old age group is 3.
5% (P=0.
005); ➤After excluding LADA patients, the incidence of T1D in all people and adults is still increasing (P <0.
05)
.

 In 2007, the incidence of T1D in the 15-29-year-old group was about 2.
12 times higher than that in the ≥30-year-old group.
However, by 2017, the incidence of the 15-29-year-old and ≥30-year-old group was almost the same
.

 Assuming that the same trend continues, it is predicted that by 2022, the number of new T1D cases in this cohort will increase to 973, and it will increase by 1.
57 times compared with 2017 in 2027
.

 Summary of this article In general, although the incidence of T1D in the Chinese population is relatively low, there are more new cases of T1D each year than previously recognized
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From 2007 to 2017, in this cohort, the incidence of T1D increased from 2.
72 per 100,000 to 3.
60 per 100,000
.

The annual incidence of T1D increases rapidly in the overall population and in people over 30 years old, but does not increase in younger people
.

This indicates that the predisposing factors of T1D in adults may be different from those in young people, and this difference can provide clues to the cause of the improvement of health services
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 Yimaitong compiled and compiled from: Liu C, Yuan YC, Guo MN, et al.
Incidence of Type 1 Diabetes May Be Underestimated in the Chinese Population: Evidence From 21.
7 Million People Between 2007 and 2017[J].
Diabetes Care, 2021, 44(11):2503-2509.