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Long-lived elderly (especially centenarians) who are the model of aging of human health not only have significantly extended life span, but also can delay or even avoid the occurrence of some major geriatric diseases.
revealits its health aging protection mechanism, which will provide a new perspective and a new strategy for delaying aging and improving the health of the elderly.
recently, the Team of Kong Qingpeng of Kunming Institute of Zoology of the Chinese Academy of Sciences, Zhou Jumin And Professor Cai Wangwei of Hainan Medical College obtained and analyzed the data of peripheral blood leukocyte transcription group (RNA-seq) of 171 samples from Hainan Longevity Family Department (centenarians, centenarians F1 descendants and F1 descendants spouses).
based on a series of biopsy strains and a sample of longevity, serum Beclin1 level tests, the researchers found that autophagy-lysozyzytic signaling pathwaygene expression was the most significant signal for centenarians, and that the signal also existed in centenarianf 1 offspring.
In view of the autophagy-participatory autophagy involved in the autophagy of the cells that can selectively degrade the damaged cells and proteins in the cell, and release free small molecules for cell reuse, the team selected four autophagy-lysozysosome signaling pathway genes (CTSBB, ATP6V0C, WIPI1 and ATG4) to further confirm that autophagic-lysozye signaling pathways enhanced functionality to delay aging and promote longevity. D) In human embryo pulmonary fibroblast IMR-90, respectively, expressed experiments, found that these four gene high expression can enhance the autophagy function and significantly delay cell aging;
, the team suggested that increased autophagy-lysosome signaling pathways could contribute to longer life expectancy for human health, based on histological analysis and other experiments such as cells and fruit flies.
published the research in the international journal Genome Research and was selected as the cover of the 11th issue of the journal.
Xiao Fuhui, Chen Xiaoqiong, Yu Qin and Ye Yunsofa of Kunming Animal Institute are co-authors of the article, Kong Qingpeng, associate researcher He Yonghui, researcher Zhou Jumin and Professor Cai Wangwei of Hainan Medical College are co-authors of the article.
the research is supported by the chinese Academy of Sciences' cutting-edge research projects, the key projects of foreign cooperation of the International Cooperation Bureau of the Chinese Academy of Sciences, and the National Natural Science Foundation of China.
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