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Neil Segil, Professor of Stem Cell Biology and Regenerative Medicine and Head and Neck Surgery at the Department of Otolaryngology, University of Southern California, said: "More than 60% of the retired population has permanent hearing loss
In the inner ear, the auditory organ, the cochlea, contains two main types of sensory cells: "hair cells", which have hair-like cell protrusions that receive sound vibrations; and "support cells" that play important structural and functional roles.
When fragile hair cells are damaged by noise, certain prescription drugs or other harmful substances, the hearing loss caused by this is permanent for older mammals
Based on these observations, postdoctoral scholar Dr.
In Sertoli cells, hundreds of genes that indicate transdifferentiation into hair cells are usually turned off
In the support cells of the cochlea of newborn mice, scientists found that hair cell genes were inhibited due to the lack of an activating molecule H3K27ac and the presence of an inhibitory molecule H3K27me3
Unfortunately, with age, the supporting cells of the cochlea gradually lose H3K4me1, causing them to exit the activated state
"Our research increases the possibility of epigenetic modification using therapeutic drugs, gene editing, or other strategies to tap the potential regenerative ability of inner ear cells as a way to restore hearing," Segil said
Litao Tao, Haoze V.