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The Research Group of the School of Life Sciences of the Chinese University of Science and Technology, in cooperation with the fu Chuan child and Yao Xuexuan, expounded that the inner kinetic protein CENP-C can be phosphorylationed by the kinase Aurora B, and played an important role in the process of microparticle-microtube connection correction in cell-splitting period as a bypass path.
research published in the Proceedings of the National Academy of Sciences (PNAS) under the title phosphorylation of CENP-C by Aurora B pleases s kineto sires ethnosy error error in mitosis.
cells distribute sister-stained monomerequally to two subcells through fission ale- cell, which is the key mechanism for the accurate transmission of cell genetic information and is of great significance to maintain genome stability.
abnormal fission division will lead to the production of polyploid cells, which will lead to tumors and other diseases, and the correct connection between the motor particles and microtubes is the cell has a normal silk division guarantee.
current studies have found that there are several outer kinetic proteins that can be phosphorydized by Aurora B to activate the spindle test point to correct the wrong connection of the particle-microtube, so that the chromosomes are properly separated.
, but the presence of inner kinetic proteins can be aurora B phosphorylation, in the kinetic-microtube connection correction process is not clear.
By analyzing the structure of the split yeast Mis12-Nnf1 complex, identifying its interface with the inner kiny kinetic protein CENP-C, and based on structural analysis and biochemical research, the 28th suchenonine of CENP-C can be aurora B phosphorylation, regulate its interaction with the Mis12 complex, and participate in the activation of the spindle-microtube strain in the process of cell sydration.
the study for the first time found that the inner kinetic protein can be phosphated by kinase, as a bypass path to regulate the activation of the spindle body test point and the correct connection of the microparticle-microtube, to deepen the understanding of the cell has filament phase genomic stability regulation mechanism.
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