The Institute of Biology, Beijing Academy of Agriculture and Forestry Sciences has made important progress in research on the regulation of Alzheimer's disease by zeoflavone isoorientin

October 12, Beijing Academy of Agriculture and Biology, maize molecular breeding research team in collaboration with the University of Hawaii Professor Qing X.

This study took Alzheimer's disease model APP/PS1 mice as the research object, and explored the mechanism of action of isoorientin by feeding the natural product isoorientin extracted from corn filaments

Based on all the test results, it is preliminarily speculated that the mechanism of isoorientin slowing down Alzheimer’s disease-related pathological indicators is: by adjusting the structure of oral and intestinal microflora, reducing the content of LPS in serum and brain tissue, thereby inhibiting LPS-induced The NF-κB inflammation pathway ultimately regulates and slows down Alzheimer's disease-related pathological indicators through the brain-gut axis

Associate researcher Zhang Zhongbao, Institute of Biology, Beijing Academy of Agriculture and Forestry Sciences, and Dr.

ABSTRACT

Background