The Institute of Zoology collaborated to establish a cell lineage landscape database

Cell lineage formation and transformation undergoes complex transcriptional and epigenetic alterations
throughout the mammalian lifespan.
In-depth study of lineage differentiation, maintenance, and degeneration provides a comprehensive understanding of important biological processes
such as organ development, homeostasis, aging, and disease.
With the rapid development of high-precision multi-omics technology, genealogy related studies on model organisms such as humans and mice have generated massive data.
It has become an urgent need
to establish a relevant data resource platform for storing, managing, and integrating multi-omics data.

On October 28, 2022, the Liu Guanghui Research Group of the Institute of Zoology, Chinese Academy of Sciences, the Zhou Yuanchun Research Group of the Computer Network Information Center of the Chinese Academy of Sciences, the Qu Jing Research Group of the Institute of Zoology, Chinese Academy of Sciences, and the Zhang Weiqi Research Group of the Beijing Institute of Genomics (National Center for Bioinformatics) collaborated at Nucleic Acids The journal Research published the paper "Lineage Landscape: a comprehensive database that records lineage commitment across specie" and established the multi-lineage panoramic database of cells "Lineage Landscape.
" (LL)", from different levels of transcriptome, single-cell transcriptome, epigenome and other levels, capturing the changes of cell lineage from embryonic, fetal, adult to senile in more than 10 species such as humans and classical model organisms.
The convergence and fusion of gene expression changes under different conditions were realized.

The Lineage Landscape database realizes the collection and integration
of multidimensional omics data at different levels and at different times of cell lineage.
Users can easily access and query the changes of genes of interest in different species and different stages of
development.
Overall, Lineage Landscape collected data from more than 6.
6 million cells, including 15 million differentially expressed gene entry information
.
The database will continuously update and integrate high-quality datasets at different omics levels, thus providing a valuable resource
for related research areas.
In addition, the team established the Aging Atlas (AA) database in 2020 and the Regeneration Roadmap (RR) database
in 2021.
These databases have so far served 160,000 visitors
from 75 countries around the world.
The three sister libraries of Lineage Landscape (LL), Aging Atlas (AA) and Regeneration Roadmap (RR) will complement each other to advance the disciplines of development, aging and regenerative biology
.

The database is jointly completed
by the Institute of Zoology, Chinese Academy of Sciences, Beijing Institute of Stem Cell and Regenerative Medicine, Computer Network Information Center of Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Science Data Center of Chinese Academy of Sciences, Data Center of Chinese Academy of Sciences, Beijing Institute of Genomics, Chinese Academy of Sciences, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital of Capital Medical University and other institutions.
Researcher Liu Guanghui of the Institute of Zoology, Chinese Academy of Sciences, Zhou Yuanchun, researcher of the Computer Network Information Center of the Chinese Academy of Sciences, Qu Jing, researcher of the Institute of Zoology, Chinese Academy of Sciences, and Zhang Weiqi, researcher of the Beijing Institute of Genomics, Chinese Academy of Sciences, are the co-corresponding authors
.
Yan Haoteng, doctoral candidate of Capital Medical University, Wang Ronghao, assistant engineer of Computer Network Information Center, Chinese Academy of Sciences, Ma Shuai, researcher of "Zhiyi", Institute of Zoology, Chinese Academy of Sciences, Beijing Institute of Stem Cell and Regenerative Medicine, Huang Daoran, engineer of Computer Network Information Center of Chinese Academy of Sciences, and researcher of National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital of Capital Medical University Wang Si and Ren Jie, a researcher at the Beijing Institute of Genomics, Chinese Academy of Sciences, are co-first authors
.
In addition, the database construction was also supported
by Chen Xin, senior engineer of the Computer Network Information Center of the Chinese Academy of Sciences, and Lu Changfa, senior engineer.

Article link: https://doi.
org/10.
1093/nar/gkac951

Database (LL) link: http://data.
iscr.
ac.
cn/lineage/#/home

Database (AA) link: https://ngdc.
cncb.
ac.
cn/aging/index

Database (RR) link: https://ngdc.
cncb.
ac.
cn/regeneration/index

Figure 1.
Lineage Landscape database