The interaction between liquorice and chemicals

2015-11-30 classification: efficacy and action 0 people comment on Glycyrrhiza uralensis Fisch It is a commonly used medicine in the formula of my scarf medicine and also the main component of Xiaochaihu Decoction Its main pharmacological active ingredient is glycyrrhizic acid, which also contains glycyrrhizin, glycyrrhizin, isoliquiritigenin, new H oxaloside, new isoschistin, etc In vitro study showed that the isoflavone glycyrrhizin extracted from Glycyrrhiza uralensis Fisch Could inactivate CYP3A4, and had time concentration dependent effect Studies in mice showed that repeated treatment with Glycyrrhiza extract and glycyrrhizic acid increased the metabolism of CYP3A4 substrate and induced CYP3A4 at mRNA and protein levels The main component of Glycyrrhiza is the ligand of nuclear receptor PXR, which can activate PXR effectively and up regulate the expression of CYP3A4, while the downstream target gene of PXR also includes MDR1.