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The correct extension of nerve bursts is essential for the formation of neural networks.
's research over the past few decades has found dozens of guided signal molecules that act on the growth cone surface receptors and control the targeted extension of nerve bursts by regulating the dynamic motion of the cytoskeleton.
however, neuronal axes and dendrites often encounter multiple guiding signals during growth and extension, and the mechanism of how neurons interpret multiple different signals simultaneously and make the ultimate single choice is not entirely clear.
the Ding Mei research team at the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences found that nematode RME nerve bursts were exposed to both Slit and Wnt signaling molecules during the extension process.
Although RME neurons express Slit receptor-Robo, their extension is not regulated by Slit.
, Robo formed a receptor complex with the tyrosine receptor family of Sole receptor Ror2, which helps with the transmission of the Wnt signal.
the only homologous protein in the Robo online worm, SAX-3, binds directly to the Wnt molecule and, in conjunction with other Wnt receptors, transmits the signal to the downstream effect molecule Dsh.
Dsh protein is an important driver of RME neuroprostrusis extension, which aggregates in the growth side of RME nerve protrusions.
Robo has an asymmetric distribution similar to Dsh, and the polarity distribution of Dsh depends on Robo.
this suggests that Robo's asymmetric distribution promotes the extension of RME nerve bursts in a specific direction.
the study reveals the interaction mechanism between the Robo receptor and the Wnt-Ror signaling pathway, and suggests that, when different signal molecules coexist, receptors that were supposed to be targeting a particular signal can actually transform their sensing traits by interacting with other receptors.
the discovery of this phenomenon, it will help to improve the understanding of how nerve suddens integrate different signals in complex physical environment, and provide new insights for exploring the mechanism of neural network development and regulation. On February 20,
, the results were published online in PNAS, with Wang Jiaming, a doctoral student in Ding Mei's research group, the first author of the paper.
research work has been supported by the NSFC and the National Key Basic Research and Development Program.
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