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On January 23, the results of the Rosa Lozano-Duran Research Group at the Shanghai Plant Adversity Biology Research Center of the Shanghai Institute of Life Sciences, Chinese Academy of Sciences, were published online in PNAS under the title A virus-targeted plant-case kinase promotes cell-to-cell of rnAi.
the study found that BAM1, a receptor protein that regulates plant growth and development, promotes the spread of RNAi between cells, revealing the key role of BAM1 in plant antiviral immunity, making the use of biotechnology to edit the protein to improve crop resistance to viruses.
diseases caused by the virus cause serious losses in agricultural production worldwide and a mortal threat to food security.
plant virusinfectes plant cells and attacks the internal components of cells for their own replication and spread, eventually leading to disease.
, however, plant cells have "learned" to detect virus invasions and to fight the virus by stimulating an immune response.
plant's main immune response mechanism against viral infection is RNA-l, which blocks viral protein replication and thus affects the virus's infection process.
RNAi relies on the production of small RNAs, which contain information about viral gene sequences that can be used to propel the plant's defense systems against virus attacks. One of the most striking features of
RNAi is the passability: small RNAs can move between cells, passing on alerts for virus intrusions in the body.
the movement of small RNAs is critical to the defense mechanism sin-checking virus, as it puts long-distance uninfected cells on alert early and prepares for defense before the virus arrives.
the biological significance of small RNA migration is closely related to the mechanism of plant virus infection prevention, the specific mechanism of small RNA movement between cells is still unclear.
study found that the receptor protein BAM1, which regulates plant growth and development, can promote the spread of RNAi between cells in the battle between plant viruses and host cells.
BAM1 protein is positioned in cells in cell membranes and intercellular fissures.
intercellular filaments are channels adjacent to intercellular connections and may help small RNAs carry information to spread.
However, as a result of the co-evolution of host and pathogens during the evolution process, if a host protein plays a prominent role in the immune response, pathogenic pathogens must also evolve to counter the effectiveness of host proteins. in addition
, the team found that a viral protein called C4 binds to BAM1, which can interfere with transmission between RNAi cells.
the study provides a basis for a deeper study of the mechanism of transmission between RNAi cells and provides new ideas for improving crop disease resistance through bioengineering.
research work has been funded by the Chinese Academy of Sciences, the National Natural Science Foundation, the Chinese Academy of Sciences "100-person program", plant and microbiological sciences joint center of excellence research.
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