The key role of three proteins in killing cancer cells

Recently, researchers at the University of Tel Aviv (tau) in Israel revealed the key role of three proteins in killing cancer cells in the Journal oncotarget The study was conducted by Malka of tau medical college Professor Cohen Armon led them to find that these proteins can be specifically modified in the process of cell mitosis, thus releasing an internal "death mechanism" - eradicating the self replication of cancer cells, and verifying in a variety of tumor cells, including breast cancer, lung cancer, ovarian cancer, colorectal cancer, pancreatic cancer, blood cancer, brain cancer, etc Professor Cohen Armon said the mechanism can kill cancer cells without damaging healthy cells (http://www.chemdrug.com/article/7/) According to this mechanism, the faster the proliferation of cancer cells, the faster and more efficient the eradication The mechanism of mitotic release may be applicable to aggressive tumors that are not affected by traditional chemotherapy The newly discovered mechanism involves the modification of specific proteins, which affect the structure and stability of the spindle The researchers found that some compounds, such as phenanthridine derivatives, can weaken the activity of these proteins, deform the spindle structure and prevent chromosome segregation Once these proteins are modified, cell separation is stopped, accelerating cell self destruction This mechanism may become a new target of cancer research The researchers said the study used phenanthroline derivatives for testing, but other drugs that modify these proteins (http://www.chemdrug.com/) can also be used to destroy cancer cells The researchers used cultured cancer cells and mice implanted with human cancer cells (http://www.chemdrug.com/sell/24/), and used biochemical, molecular biology and imaging techniques to observe this mechanism In mice implanted with three negative breast cancer cells, they observed tumor growth arrest Professor Cohen Armon said, "recognition mechanism and its relevance to tumor treatment have opened up a new way to eliminate malignant tumors." At present, they are exploring the potential of phenanthridine derivatives in the treatment of pancreatic cancer and triple negative breast cancer.