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The long-term existence of negative emotional memory caused by addiction withdrawal is the key factor that causes addicts to relapse.
is an important stage of long-term memory processing, which provides a "window" for intervention to destroy long-term pathological memory.
but the memory re-consolidation of the addiction stage and its transcription control mechanism is not clear.
the Minnan Research Group of the Institute of Psychology of the Chinese Academy of Sciences used the morphine-naloxone-induced conditional location aversion (CPA) paradigm to explore this problem by injecting DNA methylation inhibitor 5-aza through nuclear group location.
rats after CPA training formed a morphine withdrawal-related negative emotional memory, after a short period of exposure to environmental conditions to extract the memory, thereby inducing the re-consolidation process.
researchers injected 5-aza into the key brain regions of the island's leaves and amygdala, respectively, and found that DNA methylation inhibited in the island's leafy AI sub-region, then consolidated and destroyed, and CPA was inhibited for a long time.
inhibits DNA methylation in the amygdala BLA sub-region, and then consolidation is weakened, and CPA cannot be maintained after 14 days.
injections of 5-aza in the leaf GI sub-region of the island and the CeA sub-region of the amygdala, injection of 5-aza in AI and BLA without memory extraction, could not interfere with the keeping of CPA.
this study is the first to find that DNA methylation plays an important role in the re-consolidation of addiction withdrawal memory, and it also found that island leaf AI and amygdala BLA sub-regions may play different regulatory roles in the re-consolidation of negative emotional memory.
this provides new evidence for exploring new targets for interfering with addictive memory, and it is necessary to further explore the internal molecular mechanisms of DNA methylation to regulate addictive memory in the future.
the study was funded by the "973" project (2015CB553501), the National Natural Science Foundation of China (91332115, 31170988, 31400880 and 31428008) and the Chinese Academy of Sciences Mental Health Key Laboratory.
article has now been published in Frontiers in Behavioral Neuroscience.
: Liu, P. , Zhang, J., Li, M., Sui, N. (2016). Character Roles of 5-aza-2'-deoxycytidine in Anterior Agranular Insular and Basolateral Amygdala in Reconsolidation of Aversive Memory Associated with Morphine in Rats.Front Behav Neurosci, 10,50.