The key to reversing brain stem cell aging is that the environment is soft enough.

OPCs cells are keyhardening of the brain can seriously affect the function of brain stem cellsThe researchers compared the brains of young and older mice and found that brain hardening affected the central nervous system's multi-functional stem cell population, opCs, which are less protogencells(OPCs)in a healthy brain, OPCs cells are essential for maintaining brain function and myelin regenerationMyelin is a layer of fatty matter that wraps around the axons of nerve cellsAs we age, the function of these cells tends to declinePrevious studies have shown that damaged myelin or the death of OPCs cells can lead to diseases such as cerebral palsy and multiple sclerosis (MS)to determine whether the loss of function of aging OPCs cells is reversible, the researchers transplanted OPCs cells from older rats into the softer brains of younger ratsAfter the transplant, the researchers observed that aging OPCs cells began to become younger and healthierto remove the "ear-to-ear"what is re-energizing the aging stem cells? In a further study, the researchers used biosynthetic stents of different hardnesses to simulate brain stiffness and to grow brain stem cells on the stentsresults have found that a protein called PIEZO1 is the key to controlling stem cell agingThe PIEZO1 protein is present on the cell surface, and it is like an "ear-to-ear god" that tells the cell's surroundings whether it is soft or stiffSo, can you stop brain stem cells from aging simply by "solving" the PIEZO1 protein, the ear-to-ear god?remove the PIEZO1 protein before and after cell comparison
researchers removed the PIEZO1 protein on the surface of the aging brain stem cells and found that even if grown on hard material, the aging stem cells can be re-energizedmore importantly, after the researchers removed the PIEZO1 protein from the brains of older rats, OPCs cells rejuvenated and were able to take on their normal regeneration function again "For the stem cells we study at least, aging is not driven by the cells themselves," said Dr Kevin Chalut, a biophysicist at the University of Cambridge, environmentally affected by cell aging On the contrary, it is largely affected by the environment The real significance of this study is to show that the hardness of the brain environment drives the aging of stem cells asked by whether the study could be used to reverse aging in the body or to treat age-related diseases such as Alzheimer's, Chalut said: "We have every reason to believe that the mechanical properties of tissueplay play a very important role in aging Our research may contribute to a variety of brain diseases, including Alzheimer's disease, but the most obvious is multiple sclerosis (MS) "
References: s S S S S S S S : Nature: The Way to Reverse Brain Aging, in RAT IN RAT STEM CELLS SAgeing Seinging Ing ing Ingham Sin- Rat Stem stem stem The key is that the growth environment is soft enough.