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The Lancet Gastroenterology & Hepatology: Ursodeoxycholic acid can be used to prevent symptomatic gallstone disease after bariatric surgery

 Last Update: 2022-01-07
 Source: Internet
 Author: User

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Ursodeoxycholic acid can dissolve gallstones, but this drug is only effective for cholesterol stones, and has no effect on melanin stones and bile pigment stones

This is a multicenter, double-blind, randomized, placebo-controlled trial involving patients with intact gallbladder who plan to undergo laparoscopic Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy

From January 11, 2017 to October 22, 2018, 985 patients were randomly assigned to receive ursodeoxycholic acid (n=492) or placebo (n=493)

This study confirmed that the prevention of ursodeoxycholic acid did not significantly reduce the incidence of symptomatic gallstone disease in all patients after bariatric surgery

SylkeHaal.

Ursodeoxycholic acid for the prevention of symptomatic gallstone disease after bariatric surgery (UPGRADE): a multicentre, double-blind, randomised, placebo-controlled superiority trial.

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