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Since 1980, the prevalence of obesity in most countries around the world has started to rise quietly
July 2021 No.
Since 1980, the prevalence of obesity in most countries around the world has started to rise quietly
In total, China is estimated to have 85 million 18-69-year-old adults (48 million men and 37 million women) who are obese, three times as many as in 2004.
The good news is that, in addition to weight-loss pills and weight-loss surgery, scientists have recently discovered the secret that some people eat crazy and don’t get fat
DOI: 10.
1126/science.
abf8683 In this study, researchers sequenced the exomes of 645,626 individuals from the United Kingdom, the United States, and Mexico , and estimated the association of rare coding variants with body mass index (BMI) .
Exome sequencing researchers identified 16 genes, and their rare mutations in the protein coding sequence are significantly associated with high or low BMI .
Among these 16 genes, GPR75 has received special attention .
About 4 / 10,000 population sequencing hair now GPR75 truncated protein variants (protein-truncating variant), heterozygous carriers risk of obesity decreased 54%, BMI values generally lower than 1.
8 groups, 5.
3 kg light weight .
Genes related to BMI In order to further verify the effect of this gene on body weight, the researchers knocked out GPR75 in mice and fed these and normal mice on a high-fat diet.
They found that,
Compared with wild-type, the weight gain of heterozygous Gpr75-/+ mice and knockout Gpr75-/- mice was reduced by 25% and 44%, respectively, accompanied by improvements in blood glucose control and insulin sensitivity
.
Changes in body weight gains in GPR75 knockout mice and WT mice After talking about the coding variants that do not eat fat, the researchers also discovered coding variants that are prone to obesity
.
Studies have found that rare protein truncation variants in UBR2, ANO4, and PCSK1 are associated with more than twice the odds of obesity in heterozygous carriers , similar to the harmful non-synonymous variants predicted in MC4R, which are considered to be the most common cause of monogenic obesity Reason
.
In addition, protein truncation variants in CALCR are associated with higher BMI and obesity risk, and LEP, POMC, PCSK1, and MC4R (but not LEPR) are associated with higher BMI
.
These results show that sometimes obesity is really not your fault, it is the pot of genes in the body
.
But the good news is that inhibiting these obesity genes, such as GPR75, may be a treatment strategy for obesity
.
Leave a message here
The good news is that, in addition to weight-loss pills and weight-loss surgery, scientists have recently discovered the secret that some people eat crazy and don’t get fat
July 2021 No.
Since 1980, the prevalence of obesity in most countries around the world has started to rise quietly
In total, China is estimated to have 85 million 18-69-year-old adults (48 million men and 37 million women) who are obese, three times as many as in 2004.
The good news is that, in addition to weight-loss pills and weight-loss surgery, scientists have recently discovered the secret that some people eat crazy and don’t get fat
The good news is that, in addition to weight-loss pills and weight-loss surgery, scientists have recently discovered the secret that some people eat crazy and don’t get fat
DOI: 10.
1126/science.
abf8683 In this study, researchers sequenced the exomes of 645,626 individuals from the United Kingdom, the United States, and Mexico , and estimated the association of rare coding variants with body mass index (BMI) .
Exome sequencing researchers identified 16 genes, and their rare mutations in the protein coding sequence are significantly associated with high or low BMI .
Among these 16 genes, GPR75 has received special attention .
About 4 / 10,000 population sequencing hair now GPR75 truncated protein variants (protein-truncating variant), heterozygous carriers risk of obesity decreased 54%, BMI values generally lower than 1.
8 groups, 5.
3 kg light weight .
Genes related to BMI In order to further verify the effect of this gene on body weight, the researchers knocked out GPR75 in mice and fed these and normal mice on a high-fat diet.
They found that,
Compared with wild-type, the weight gain of heterozygous Gpr75-/+ mice and knockout Gpr75-/- mice was reduced by 25% and 44%, respectively, accompanied by improvements in blood glucose control and insulin sensitivity
.
Changes in body weight gains in GPR75 knockout mice and WT mice After talking about the coding variants that do not eat fat, the researchers also discovered coding variants that are prone to obesity
.
Studies have found that rare protein truncation variants in UBR2, ANO4, and PCSK1 are associated with more than twice the odds of obesity in heterozygous carriers , similar to the harmful non-synonymous variants predicted in MC4R, which are considered to be the most common cause of monogenic obesity Reason
.
In addition, protein truncation variants in CALCR are associated with higher BMI and obesity risk, and LEP, POMC, PCSK1, and MC4R (but not LEPR) are associated with higher BMI
.
These results show that sometimes obesity is really not your fault, it is the pot of genes in the body
.
But the good news is that inhibiting these obesity genes, such as GPR75, may be a treatment strategy for obesity
.
Leave a message here
