The Lancet Oncology: Excluding ethnic factors in the assessment of renal function may affect the treatment of black cancer patients

• A retrospective analysis of 340 black cancer patients participating in the first phase of clinical trials in the United States between 1995 and 2010 showed that the number of CKD-EPI equations that exclude race may reduce the number of black cancer patients deemed eligible for resistance.

  
  

• If race is excluded from the CKD-EPI equation, as many as 5% and 18% of patients in the analysis will be excluded from treatment or receive lower dose recommendations

  
  

• The equation of race agnosticism has been proposed, but more work is needed to allow a wide range of clinical applications

  
  

• The results of the study emphasize the need to consider the use of race-based adjustments, careful and precise clinical judgments, and patient-centered methods to explain and compare the complexity of renal function estimation in different gfr estimation equations

  
  

Elimination of race factors in the kidney function-estimating equation is used to guide cancer treatment doses and qualifications that may reduce the proportion of black patients.

The Chronic Kidney Disease-Epidemiology Cooperation (CKD-EPI) equation estimates a key indicator of kidney function, called glomerular filtration rate (GFR)

Since the kidney is the main organ that removes substances from the body, clinicians can use the CKD-EPI equation to help determine the eligibility and dosage of anticancer drugs for cancer patients

Dr.

The co-author of the study, Dr.

The author conducted a retrospective analysis of 340 black patients who were included in the Phase I clinical trial of the National Cancer Institute of the United States from 1995 to 2010

The CKD-EPI equation was used to estimate the patient's renal function, and race was used as a variable

The median glomerular filtration rate calculated by CKD-EPI was 103 mL/min, while the median glomerular filtration rate calculated by CKD-EPI without ethnic factors was 89 mL/min

Since the elimination of race in the CKD-EPI equation reduces the number of patients who are recommended to use or receive full-dose anticancer drugs, the authors admit that doing so may reduce the toxicity of anticancer drugs, but further research is needed

The authors also admit that their research has some limitations

Dr.

DOI 10.

Effect of removing race from glomerular filtration rate-estimating equations on anticancer drug dosing and eligibility: a retrospective analysis of National Cancer Institute phase 1 clinical trial participants