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▎Human papillomavirus (HPV), edited by WuXi AppTec's content team, is one of the common sexually transmitted infections in women, and it is also the cause of cervical cancer, genital warts and other diseases
.
HPV vaccination provides an important means to prevent HPV infection and the prevention and control of related diseases, but some people are also worried about the safety of HPV vaccines
.
A recent study published in The Lancet Regional Health-Europe evaluated the association between HPV vaccines and non-targeted infectious diseases
.
Research results do not support that HPV vaccination will increase the risk of a variety of non-specific infectious diseases
.
Screenshot source: The Lancet Regional Health-Europe study included a total of 853,879 women between the ages of 10 and 29 in Denmark, and included information about their quadrivalent HPV vaccination status and medical treatment due to infectious diseases
.
In this cohort, the investigator conducted a self-controlled case series (SCCS) analysis, comparing the hospitalization rate in the main risk period of 90 days after the latest vaccination with the hospitalization rate in the reference period (reference period rates) A comparison was made, and the hospitalization risk was adjusted according to age and season of onset
.
In the study, 502,269 participants received 13,44915 doses of HPV vaccine
.
Among girls aged 10-17, the median age of HPV vaccination was 12.
9 years, and among women aged 18-29, the median age of vaccination was 23.
9 years
.
A total of 65,293 patients were identified among the subjects who were hospitalized for four types of infectious diseases, including upper respiratory tract infection, lower respiratory tract infection, gastrointestinal infection and other infections
.
For all diseases, the youngest subjects had the lowest incidence; gastrointestinal infections peaked in summer, while upper respiratory tract infections and lower respiratory tract infections peaked in winter
.
Among them, 37,003 vaccinated subjects experienced 46,955 hospitalizations during the follow-up period and were included in the SCCS analysis
.
During the 90-day main risk period, there was no statistically significant increase in the risk of hospitalization for infectious diseases in the vaccinated population and the control group
.
Considering that the hospitalization rate for respiratory tract infections may change due to seasons, the research team further analyzed the results after cross-season impact analysis and found that seasonal changes had no effect on the main risk outcome
.
The paper concluded that: A self-controlled case series analysis of 46,955 hospitalized patients with infectious diseases found that it did not support the hypothesis that “HPV vaccination will increase the risk of non-specific infectious diseases”
.
Ninety days after the last vaccination, it did not show any increased risk, indicating that the HPV vaccination had no long-term negative effects
.
Related reading Is HPV vaccine safe? BMJ published the follow-up results of 33 types of health conditions of 440,000 girls in Asia.
What is the effect of HPV vaccination? The latest Chinese application expert consensus: all your doubts are here.
WHO's latest cervical cancer screening guidelines: the preferred method change.
These 16 recommendations are for all women of the right age to understand! How long does the HPV vaccine last? "Lancet" sub-published data for more than 10 years: long-term access to antibodies, and "extra" cross-protection! HPV vaccine for girls of school-age age will reduce cervical cancer by 90% in China in the future! The International Agency for Research on Cancer emphasizes the benefit of key populations.
Source: 123RF Reference Materials [1] Hviid, A.
, & Laksafoss, A.
(2021).
Quadrivalent human papillomavirus vaccination and non-targeted infectious disease hospitalisation: Population-based self- controlled case series analysis.
The Lancet Regional Health-Europe, DOI: https://doi.
org/10.
1016/j.
lanepe.
2021.
100189 Disclaimer: WuXi AppTec's content team focuses on introducing global biomedical health research progress
.
This article is for the purpose of information exchange only.
The opinions expressed in the article do not represent the position of WuXi AppTec, nor does it mean that WuXi AppTec supports or opposes the views in the article
.
This article is not a treatment recommendation either
.
If you need guidance on the treatment plan, please go to a regular hospital for treatment
.
.
HPV vaccination provides an important means to prevent HPV infection and the prevention and control of related diseases, but some people are also worried about the safety of HPV vaccines
.
A recent study published in The Lancet Regional Health-Europe evaluated the association between HPV vaccines and non-targeted infectious diseases
.
Research results do not support that HPV vaccination will increase the risk of a variety of non-specific infectious diseases
.
Screenshot source: The Lancet Regional Health-Europe study included a total of 853,879 women between the ages of 10 and 29 in Denmark, and included information about their quadrivalent HPV vaccination status and medical treatment due to infectious diseases
.
In this cohort, the investigator conducted a self-controlled case series (SCCS) analysis, comparing the hospitalization rate in the main risk period of 90 days after the latest vaccination with the hospitalization rate in the reference period (reference period rates) A comparison was made, and the hospitalization risk was adjusted according to age and season of onset
.
In the study, 502,269 participants received 13,44915 doses of HPV vaccine
.
Among girls aged 10-17, the median age of HPV vaccination was 12.
9 years, and among women aged 18-29, the median age of vaccination was 23.
9 years
.
A total of 65,293 patients were identified among the subjects who were hospitalized for four types of infectious diseases, including upper respiratory tract infection, lower respiratory tract infection, gastrointestinal infection and other infections
.
For all diseases, the youngest subjects had the lowest incidence; gastrointestinal infections peaked in summer, while upper respiratory tract infections and lower respiratory tract infections peaked in winter
.
Among them, 37,003 vaccinated subjects experienced 46,955 hospitalizations during the follow-up period and were included in the SCCS analysis
.
During the 90-day main risk period, there was no statistically significant increase in the risk of hospitalization for infectious diseases in the vaccinated population and the control group
.
Considering that the hospitalization rate for respiratory tract infections may change due to seasons, the research team further analyzed the results after cross-season impact analysis and found that seasonal changes had no effect on the main risk outcome
.
The paper concluded that: A self-controlled case series analysis of 46,955 hospitalized patients with infectious diseases found that it did not support the hypothesis that “HPV vaccination will increase the risk of non-specific infectious diseases”
.
Ninety days after the last vaccination, it did not show any increased risk, indicating that the HPV vaccination had no long-term negative effects
.
Related reading Is HPV vaccine safe? BMJ published the follow-up results of 33 types of health conditions of 440,000 girls in Asia.
What is the effect of HPV vaccination? The latest Chinese application expert consensus: all your doubts are here.
WHO's latest cervical cancer screening guidelines: the preferred method change.
These 16 recommendations are for all women of the right age to understand! How long does the HPV vaccine last? "Lancet" sub-published data for more than 10 years: long-term access to antibodies, and "extra" cross-protection! HPV vaccine for girls of school-age age will reduce cervical cancer by 90% in China in the future! The International Agency for Research on Cancer emphasizes the benefit of key populations.
Source: 123RF Reference Materials [1] Hviid, A.
, & Laksafoss, A.
(2021).
Quadrivalent human papillomavirus vaccination and non-targeted infectious disease hospitalisation: Population-based self- controlled case series analysis.
The Lancet Regional Health-Europe, DOI: https://doi.
org/10.
1016/j.
lanepe.
2021.
100189 Disclaimer: WuXi AppTec's content team focuses on introducing global biomedical health research progress
.
This article is for the purpose of information exchange only.
The opinions expressed in the article do not represent the position of WuXi AppTec, nor does it mean that WuXi AppTec supports or opposes the views in the article
.
This article is not a treatment recommendation either
.
If you need guidance on the treatment plan, please go to a regular hospital for treatment
.
