The largest study to date shows that vitamin D does not prevent diabetes

The wind of vitamin D supplementation has been blowingLast year's vital study showed that vitamin D did not affect the risk of cardiovascular events or cancer; this time, the "legend" of vitamin D preventing diabetes was also puncturedDaily vitamin D supplementation does not prevent type 2 diabetes in high-risk adults, the study found, published online in the New England Journal of medicine< br / > Image Source: New England Journal of medicine < br / > Although previous observational studies have shown that low vitamin D levels are related to the increased risk of type 2 diabetes, and small studies have found that vitamin D can improve the function of islet β cells, there is no definite evidence that vitamin D supplementation can help prevent or delay the onset of type 2 diabetes< br / > the trial named "vitamin D and type 2 diabetes (D2D)" was funded by the National Institute of Health (NIH) National Institute of diabetes, digestive and kidney disease (NIDDK)It has included 2423 adults in pre diabetes period in 22 centers in the United StatesIt is the largest study so far to directly verify the prevention effect of daily vitamin D supplementation on type 2 diabetes< br / > at the study baseline, about 80% of the subjects' serum vitamin D levels were found to be below the US nutritional standardSubjects were randomly assigned to receive 4, 000 international units (IU) of vitamin D3 (1211 people) or placebo (1212 people) per day and diabetes screening every 3-6 monthsSubjects were required to avoid diabetes or weight-loss drugs during the study period and limit their vitamin D intake to less than 1000 IU per day in the trial diet supplement< br / > in an average follow-up of 2.5 years, although the serum vitamin D level in vitamin D group nearly doubled, there was no statistical difference in the risk of diabetes between the two groups24.2% of the population in vitamin D group developed diabetes, compared with 26.7% in placebo groupThere was no difference in safety between the two groups, such as hypercalcemia and nephrolithiasis< br / > in addition to the scale of the study, another advantage of this study is the diversity of subjectsFurther analysis of age, gender, race, and ethnicity led to consistent conclusions that vitamin D did not prevent diabetes, the researchers said< br / > although vitamin D has not been proved to be effective, DrGriffin P Rodgers, director of NIDDK, stressed, "we are far from helpless with type 2 diabetes, and even the high-risk population is still expected to delay the onset of the disease According to the research of DPP funded by NIDDK, metformin and lifestyle intervention can effectively prevent type 2 diabetes, and we will continue to find effective prevention methods " < br / > references < br / > [1] ANASTASIOS g, et al (2019) Vitamin D supply and prevention of type 2 diabetes N Engl J Med, 10.1056/nejmoa190906 < br / > [2] NIH funded trial finds vitamin D does not prevent type 2 diabetes in people at high risk Retrieved Jun 11, 2019, From < br / >! The largest study to date shows that diabetes is not prevented