The latest article by Dr. Wei Wei: The first analysis of fatty acid metabolism in cancer cells with single-cell resolution

Fatty acids, glucose and amino acids are the main energy sources for cell growth and proliferation.

However, unlike glucose and amino acids, the mechanism by which fatty acids enter cells is poorly understood and difficult to identify

Recently, researchers from the University of California, Riverside, ISB Institute developed a series of chemical probes and analytical methods that can analyze how fatty acids in individual cells are absorbed.

Dr.

In order to analyze the intake of fatty acids, the researchers chose a substitute molecule with a structure similar to that of natural fatty acids

Applying this new single-cell tool to a brain cancer model, the researchers found that fatty acid uptake is differentially regulated by two downstream effectors of mammalian target of rapamycin (mTOR): target of rapamycin is cell proliferation And a key regulator of protein synthesis

"This new tool opens up new avenues for studying how fatty acid metabolism affects biological systems

Original title:

Zhili Guo, Hanjun Cheng, Zhonghan Li, Shiqun Shao, Priyanka Sarkar, Siwen Wang, Rohit Chaudhuri, Nicole G.