The latest autopsy report is released, the virus will spread throughout the body after the new crown infection!

The most significant pathological change of the new crown infection is the destruction of the normal tissue structure of the lungs and respiratory tract
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However, clinically, new coronary infection often leads to multiple organ failure and shock, and some survivors also experience acute sequelae after infection, often accompanied by cardiovascular, pulmonary and neurological symptoms
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However, it has always been a mystery how the extrapulmonary organs change after the new crown infection.
Scientists speculate that the new crown virus can directly attack multiple organs of the human body, but there is still no convincing evidence
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If it is confirmed that the new coronavirus can spread throughout the body, it will show that the harm of the new coronavirus is far greater than our perception
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Recently, an autopsy report on 44 patients who died of new crown infection has attracted attention
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In this report, the researchers systematically detected viral loads in multiple organs throughout the body, including the brain, and systematically studied the spread of the virus after infection and the differential damage to individual organs
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Among them, 38 patients developed new coronavirus antibodies, 3 cases belonged to early infection and have not yet developed specific antibodies, and 3 cases were unable to determine whether antibodies were produced due to sample reasons
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Of the 44 samples, 11 completed the sampling of brain tissue, and also included sampling of major organs of the body such as the gastrointestinal tract, liver, heart and lungs, kidneys, eyes, muscles, endocrine glands, and reproductive organs
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The male-to-female ratio of all samples was approximately 7:3, and the vast majority of patients had at least one underlying disease, of which hypertension (54.
5%) was the most common
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These patients were admitted to hospital on average 9.
4 days after symptom onset and 26.
4 days in hospital, with an average time from symptom onset to death of 35.
2 days, and the average postmortem to autopsy interval 26.
2 hours
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81.
8% of patients received invasive mechanical ventilation such as intubation, 22.
7% received extracorporeal membrane oxygenation (ECMO) therapy, and 40.
9% received renal replacement (dialysis) therapy
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In all 44 samples, a total of 85 anatomical locations and 79 kinds of body fluid samples were involved, all of which had new coronavirus RNA detected, which directly proved that the new coronavirus will spread to all parts of the body
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  In the samples of 3 early cases, the highest content of viral RNA was detected in the respiratory tract, but at the same time, the researchers also found the presence of high levels of viral RNA in other samples of the whole body of the early patients, except for reproductive organs
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This suggests that systemic spread of the virus occurs soon after infection
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Interestingly, in the middle and late stages of infection, viral RNA in whole body tissues showed a downward trend, but low levels of RNA persisted
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  Overall, 97.
7% of respiratory tract tissues were detected with new coronavirus RNA, ranking first among all anatomical sites
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90.
9% of brain tissue, 79.
5% of cardiovascular tissue, 86.
4% of lymphoid tissue, 72.
7% of gastrointestinal tissue, 63.
6% of kidney and endocrine tissue, 42.
5% of reproductive tissue and 57.
9% of ocular tissue had viruses RNA detection
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To further confirm the reliability of the detection, the researchers used in situ hybridization to directly observe the distribution of viral RNA on specimen sections
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They found that viral RNA was present throughout the respiratory tract in early cases and in the turbinate sinuses, trachea, and lungs in advanced cases
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  In addition, cardiomyocytes, endothelial cells and vascular smooth muscle contained viral RNA in both early and advanced cases
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RNA footprints were also found in aortic intimal cells
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Monocytes and colonic epithelial cells in the lymph nodes, spleen, and appendix of early cases also contained viral RNA
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In other tissues, different degrees of viral RNA were also detected by in situ hybridization
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Next, the researchers observed the pathological changes of each organ one by one
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They found that 94.
5% of the cases had pathological features of acute pneumonia or diffuse alveolar damage at the time of death
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Pulmonary thromboembolism occurred in 23% of cases, myocardial infiltration in 4 cases, and overt myocarditis in 1 case
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Significant lymphocyte depletion was observed in the lymph nodes and spleen
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  Alterations in extrapulmonary tissue are mainly related to complications or pre-existing comorbidities, for example they found 30% of liver necrosis and 39% of acute kidney injury, which may be related to hypoxic ischemic injury
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It is worth mentioning that in the examination of brain tissue, the researchers found few histopathological changes
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For example, they found that there was vascular congestion in the brain tissue, and 2 patients had ischemic changes in the whole brain
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This study is the first to directly demonstrate that 2019-nCoV spreads in multiple organs and the brain early in infection, and retains multiple extrapulmonary replication sites in the first week after onset of symptoms
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This suggests that these extrapulmonary tissues are likely to prolong the replication time of the virus, leading to difficulties in curing, and even laying the groundwork for future recurrence
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 Sohu.
com researchers believe that the main contribution of their study is to provide evidence of systemic spread of the virus, and to confirm that this spread changes over time
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For example, in the early stage, the virus content in the lungs was significantly higher than that in the outside lungs, but as the disease progressed, the virus content in the lungs and outside the lungs gradually approached
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This may be related to the weaker immune response ability of extrapulmonary tissues
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The harm of the new coronavirus goes far beyond lung damage.
More and more studies have shown that the new crown infection may cause long-term sequelae to the whole body, and the recovered patients should also be continuously tracked
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The fact that the multi-organ virus was detected also reminds us that the virus may have a latent ability that we have not yet discovered, which may be one of the reasons for the recovery of new crown patients
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However, the limitations of this study are also obvious: the researchers did not discuss the role of vaccination in the prevention and treatment of the disease
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Under the premise that the new crown vaccine has protective antibodies, the pathophysiological process of the virus is bound to be very different
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In addition, the sequelae of people who have recovered from the new crown are mostly in a controllable range, which may be far from the spread of the virus in the deceased
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More research is needed to confirm how the virus develops under the influence of the vaccine
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 References https:// Written | Organized by Guan Shuimu | Swagpp Click "Read the original text" below to download the Mace Medical APP