The latest formula for calculating the distance between the ends of a curved polymer.

Like rigid plastic models from chemistry classes, real molecular chains bend and stretch.
some DNA-like polymers are particularly stretchable.
this feature complicates efforts to model its behavior.
since Paul Flori's pioneering work, the researchers have come up with formulas for calculating the distance between the ends of curved polymers.
, however, these formulas usually do not take into account the stretching of molecules. In a new study published in the Journal of Chemical Physics by the American Federation of Physics,
scientists derived a formula for determining the distance between the two ends of semi-flexible polymers, including DNA or RNA, taking into account how stretched the polymers are.
previous estimates of how polymers bend do not explain how molecules move under three-dimensional.
researchers say the latest method of calculating the distribution of straightened lengths is more rigorous.
not only calculates the distance between the ends, but also clarifies the shape of the polymer.
by taking into account the stretching of polymers, the latest formula helps researchers estimate the flexibility of DNA fragments.
found that this property of DNA is essential for its biological function.
the flexibility of DNA affects the binding of regulatory proteins and how DNA wraps around histoproteins that are neatly "packed" into the nuclea like spools.
specific ways in which DNA bends and surrounds histone affect gene expression by exposing specific genes while hiding others.
researchers used a worm-like chain model to derive a new formula.
model used semi-flexible polymers such as DNA and RNA as a link in the chain.
a large number of Monte Carlo simulations, they have verified the validity of the formula on a large scale.
researchers also used molecular dynamics simulations to model how molecules move and interact in real time to ensure similar results for short-chain DNA and RNA polymers were obtained from their methods.
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