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How to inhibit aging and prolong lifespan has been a dream of mankind for a long time
Since the discovery of cell senescence in the 1960s, for a long time, people have always believed that senescence is a protective physiological mechanism that "inhibits the further proliferation of damaged or mutated cells", thereby inhibiting tumors
Multiple teams have discovered that senescent cells secrete a large number of pro-inflammatory exocrine molecules, which affect the structure and function of neighboring cells, leading to local or systemic chronic inflammation
This week, in a study published in "Nature-Metabolism", the team of researcher Sun Yu from the Shanghai Institute of Nutrition and Health of the Chinese Academy of Sciences discovered that the proanthocyanidin C1 (PCC1) in wild grape seed extracts can selectively induce apoptosis in senescent cells , Improve the health and life expectancy of old mice
In this study, the researchers first screened a group of organic drug banks based on natural-derived products and found that grape seed extract has the potential to selectively target senescent cells
In previous mouse studies, scientists discovered two types of anti-aging drugs with different mechanisms-senomorphics that inhibit aging-related secretion phenotypes, thereby changing the characteristics of senescent cells, and senolytics that work by eliminating senescent cells
Therefore, Sun Yu's team used a mouse model to test the effectiveness and safety of PCC1 in treating diseases and inhibiting aging
▲The study tested the effect of PCC1 on clearing mouse tumors (picture source: reference [1])
Even more gratifying are the experiments on naturally aging old mice
▲The effect of different concentrations of PCC1 on clearing senescent cells (picture source: reference [1])
While carrying out experiments in mice, this study also revealed the biological mechanism by which PCC1 plays an anti-aging effect and promotes longevity of the body
Further research revealed the mechanism by which PCC1 promotes the secretion of pro-apoptotic factors
So far, this study has demonstrated the anti-aging effect of grape seed extract as a primary plant extract, and further discovered that its core component PCC1 can selectively induce apoptosis of senescent cells
Note: The original text has been deleted
Reference materials:
[1] Xu, Q.