echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Biochemistry News > Biotechnology News > The latest paper from Nature Communications of Sichuan University: Molecular mechanism of ligand entry into Sigma-1 receptor pathway

    The latest paper from Nature Communications of Sichuan University: Molecular mechanism of ligand entry into Sigma-1 receptor pathway

    • Last Update: 2022-04-25
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    On March 10, 2022, the team of researchers Sun Ziyi and Zhou Xiaoming of the State Key Laboratory of Biotherapy/Rare Disease Center/Department of Integrative Medicine, West China Hospital, Sichuan University published online in Nature Communications entitled "An open-like conformation of the sigma -1 receptor reveals its ligand entry pathway", which revealed the molecular mechanism of ligand entry into sigma-1 receptor through PATH2 pathway


    Dr.



    Sigma-1 receptor (σ1R) is a class of non-opioid transmembrane protein receptors, mainly located in the endoplasmic reticulum membrane of cells, distributed in most organs and tissues of the human body, and mediates cell survival and various physiological activities.



    Figure 1.


    This study used X-ray crystallography to resolve for the first time the openness of Xenopus laevis σ1R (xlσ1R) to bind endogenous ligands (presumed) and exogenous ligands (agonist PRE-084, antagonist S1RA), respectively / Closed high precision 3D structure



    Figure 2.


      On the other hand, the α4 helix in the open structure of xlσ1R undergoes rotational displacement, and the tyrosine side chain at position 203 on the α5 helix rotates inward, forming an opening that allows the passage of ligands (Fig.



      Figure 3.


      In conclusion, this study resolves the open structure of Xenopus laevis σ1R by X-ray crystallography, which supports the entry of σ1R ligands into the receptor β-barrel through the opening between the α4 and α5 helices (PATH2 pathway).


      Original link: https://doi.


     

    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.