The latest paper published by the team of Academician Lu Lin: Intestinal flora mediates cognitive impairment caused by sleep deprivation

Sleep is a complex rhythmic physiological process, which is essential to human health
.

However, with the development of economy and the accelerating pace of people’s lives, sleep deprivation has become more and more common, causing people’s cognitive impairment, reduced ability to work during the day, and decline in health, which has become one of the health problems that have attracted much attention.

The pathological mechanism of cognitive impairment caused by sleep deprivation is still unclear.
In the past, it was generally believed that cognitive function was completely regulated by the central nervous system.
The concept of "axis" believes that the composition of the intestinal flora in the body and its metabolic activities will also have an important impact on the body's brain function and behavior
.

There are all kinds of microorganisms in our body, especially in the intestines, there is an intestinal microbial ecosystem, the so-called intestinal flora, in which there are more than hundreds of microorganisms, and the total amount is even more than 100 trillion

Recently, the top journal in the field of psychiatry "Molecular Psychiatry" published an online research paper titled "Gut microbiota modulates the inflammatory response and cognitive impairment induced by sleep deprivation" by the team of Academician Lu Lin, which combines clinical and basic research , It is the first time to reveal the mechanism of cognitive impairment caused by sleep deprivation from the perspective of "microorganism-gut-brain axis", providing new targets and ideas for preventing cognitive impairment caused by sleep deprivation, and for the treatment of intestinal flora through intervention Related neuropsychiatric disorders provide an important scientific basis
.

The study first conducted 40 hours of sleep deprivation on healthy adults, and found that sleep deprivation can cause disorders of intestinal flora and systemic inflammation
.

The study also found that when healthy subjects experienced sleep deprivation, cognitive functions (attention and memory) were also significantly impaired

Dr.
Zhong Wang and Dr.
Wenhao Chen from Peking University Sixth Hospital are the co-first authors of the paper, Academician Lu Lin and Assistant Researcher Yan Wei from Peking University Sixth Hospital, Associate Researcher Han Ying, and Lu Jun, China Institute of Drug Dependence, Peking University Professor Wei Hong from the Military Medical University is the co-corresponding author
.

The research was supported by the National Natural Science Foundation of China and the National Key Research and Development Program of the Ministry of Science and Technology

 

Citation information: Zhong Wang#, Wen-Hao Chen#, Su-Xia Li, Zhong-Ming He, Wei-Li Zhu, Yan-Bin Ji, Zhe Wang, Xi-Mei Zhu, Kai Yuan, Yan-Ping Bao, Le Shi, Shi-Qiu Meng, Yan-Xue Xue, Wen Xie, Jie Shi, Wei Yan*, Hong Wei*, Lin Lu*, Ying Han*.

 

Full text link: https://