The latest research advances in access to esogen intergenerative inheritance.

On February 20, the international academic journal Biological Reviews published online a commentary paper by Sun Zhongsheng of the Genomics and Epigenome Research Group of the Beijing Institute of Life Sciences of the Chinese Academy of Sciences entitled Lamarck rises from his grave: Parental environment-induced epigenetic inheritance in model organisms and humans.
paper systematically summarizes the latest research progress of the surface regulatory mechanism's participation in the obtained esogen intergenerational inheritance.
the "central law" of 20th-century genetic research holds that DNA is the carrier of genetic information and that biological character is determined by DNA sequences.
, the "accessory genetic theory" holds that life can produce physiological and behavioral changes in response to environmental changes and can be passed on to future generations.
since Lamarack put forward the famous "accessory genetic theory", whether environmental factors can pass on the obtained esope through the prescient genetic method has aroused continuous concern and discussion.
sophological genetic regulation, including DNA methylation, histogeneic modification and a variety of non-coding RNAs, can regulate gene expression without changing the DNA sequence, and participate in the regulation of physiology or behavior by a variety of environmental factors.
There is now a growing body of emogenement studies showing that changes in the environment or manner in which ancestors or parents lived, such as nutritional deficiencies or imbalances, parenting behaviour, social stress or fear, can play a role in shaping the esoteric traits of children or grandchildren.
Currently, evidence of the involvement of oscic regulatory mechanisms in the cross-generational transmission of sexual ideosphere has been found in the immune system (ly worms), longevity (moths), reproductive systems (moths), metabolic systems (worms, fruit flies, rodents and humans), and emotional and spiritual aspects (rodents).
On this basis, the team systematically summarized the genetic evidence obtained by the worm, fruit fly, zebrafish, rodent and human under various environmental factors, and made a comprehensive review of the intergenerational inheritance of the obtained ideotype.
The review discusses in detail the specific mechanisms by which obtained sexuality is transmitted to offspring by reproductive cells through specific supergenetic regulations such as DNA methylation, histogeneic modification, siRNA, miRNAs, piRNA, tRNA fragments, etc. under specific environmental factors.
the review article clearly pointed out that there are many problems in the field of intergenerational genetics of access estypes.
e.g., how environmental factors of the ancestors or parents specifically affect the exogenetic genome of reproductive cells, and how the exogengic genome of reproductive cells resists the reprogramming process in development, which in turn specifically guides the establishment of specific ode genetic markers in child-specific tissues.
to these problems, the author proposes two corresponding solutions.
First, accurate oscicular regulatory testing at the genome-wide level, at the resolution of individual cells (such as sperm or eggs), and the ability to operate on experimental animals for developmental sensitivity periods and specific oscicular genetic regulation, will help to identify and identify specific ode genetic markers of the obtained esopque cross-generational inheritance.
second, given the diversity of the exogenous genetic map among species, further research is needed as to whether the intergenerational genetic molecular mechanisms found in invertebrates also play an equally important role in mammals.
the theory of "accessory genetics" led researchers to realize that the DNA that makes up the phenomenon of life is not static, but is in close communication with the living environment, lifestyle and habits day after day.
this effect not only causes many changes in people's physiological function, but may also imprint the physical and mental health of future generations.
Therefore, a comprehensive overview and in-depth discussion of the prespicological regulatory mechanisms of accessible esoteric esoteric inheritance will help to understand how gene-environment interoperability shapes the physiological function of the body, which will have broad and long-term effects on human health and understanding biological adaptation and evolution.
this work was mainly completed by Wang Yan, an associate researcher of Sun Zhongsheng Research Team of the Beijing Academy of Health Sciences, and was supported by the "973" project of the Ministry of Science and Technology and the special research project of the public welfare industry.
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