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The latest research from Southern Medical University: Targeting copper metabolism is expected to reverse tumor radiotherapy resistance

 Last Update: 2022-03-09
 Source: Internet
 Author: User

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Radiotherapy (radiotherapy) is one of the main treatment methods for malignant tumors, and radiotherapy resistance is the main reason for limiting the efficacy of tumor radiotherapy

Metabolic disorders are an important feature of malignant tumors

Recently, the team of Professor Guan Jian from the Department of Radiotherapy of Nanfang Hospital published a research paper titled "COMMD10 inhibits HIF1α/CP loop to enhance ferroptosis and radiosensitivity by disrupting Cu-Fe balance in hepatocellular carcinoma" in the Journal of Hepatology, a top international academic journal

This study revealed a new mechanism of tumor radioresistance mediated by copper metabolism disorders

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