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Recently, Professor He Dinggeng, the modern microbiological technology team of our hospital, has made important progress in the field of efficient antibacterial nanozyme research .
" Redox Reactions for Intensive Wound Disinfection " was published online on December 16 , 2021 in the international authoritative journal Small ( Zone , IF: 13.
281 ) .
Pathogenic bacterial infection, mainly including purulent wound infection and sepsis, is a common disease that seriously threatens human health
.
The traditional strategy to fight bacterial infections is to use antibiotic drugs, but the misuse of antibiotics has led to the emergence of drug-resistant bacteria, which poses a major threat to the use of antibiotics in the future
In response to the above problems, Professor He Dinggeng et al.
developed a smart nanozyme that can consume GSH and self - supply H2O2 .
The enzyme can not only break the redox homeostasis of bacteria, but also effectively remain at the site of bacterial infection for local long-term CDT , to achieve good antibacterial effect
Hunan Normal University is the first completion unit of this paper.
Xiao Jiayu, a 2019 graduate student of our school, is the first author of the paper.
Professor He Dinggeng is the corresponding author of the paper.
The team leader, Professor Deng Le, provides important guidance for this work
( Link to the paper : https://doi.
Schematic illustration of PDA/Fe3O4 nanozyme for efficient antibacterial by depleting GSH and converting oxygen to hydroxyl radicals
