The latest research results of Zhou Binbing's research group at the Affiliated Children's Medical Center reveal: chemotherapeutic drugs can repair the lack of misalignment...

As early as 2014, the Affiliated Children’s Medical Center and the St.

July 22, 2021, National Children's Medical Center (Shanghai)/Shanghai Children's Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine, Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Zhou Binbing, Key Laboratory of Children's Hematological Tumors, National Health Commission The team, the Jinghui Zhang team of the St.

This study provides the first direct genomics and cytology experimental evidence for ALL chemotherapy drugs to induce drug-resistant mutations, indicating that the chemotherapeutic drug mercaptopurine may directly induce drug-resistant gene mutations in patients with mismatch repair defects, making tumor cells resistant to a variety of Resistance to other chemotherapeutic drugs has led to the recurrence of leukemia

The study comprehensively analyzed samples of 1951 ALL patients from China, the United States, and Germany, and found that the tumor suppressor gene TP53 R248Q mutation was significantly enriched in relapsed ALL

The results of this study provide experimental evidence that chemotherapeutics may directly induce drug-resistant mutations