The latest study aims to verify the association between AD pathology and DNA methylation.

Recent large-scale genome-wide association studies have found that several genetic variants are closely related to Alzheimer's disease (AD).
is the higher the degree of methylation of DNA at the AD site, the higher the susceptibility to disease? JAMA magazine reported on a new study by researchers such as Lei Yu to verify the link between AD and DNA methylation in 28 pathologically related gene sites in the brain.
Alzheimer's disease is a complex age-related neurodegenerative variable that is highly inheritable.
in addition to the three pathogenic genes of familial AD (e.g. APP, PSEN1 and PSEN2) and the well-known lipoprotein E gene (APOE), a wide range of genome-related studies have found and replicated common variants associated with AD susceptibility, including CR1, BIN1, CD33, CLU, ABCA7, CD2AP, PICALM, EPHA1, MS4A6, and MSA4A.
the latest meta analysis also includes HLA-DRB5, PTK2B, SORL1, SLC24A4, DSG2, INPP5D, MEF2C, NME8, ZCWPW1, CELF1, FERMT2 and CASS4.
also reported the TREM2 gene variant at risk of AD.
, the large amplification of the six nucleotide repeat sequences on the C9oborf72 gene also suggests a possible AD.
study conducted clinical pathological cohort studies of aging and dementia (religious order study or memory and aging project) on 740 autopsy results aged 66.0-108.3 years.
used microsphere analysis techniques on the outer cortex tissue of the prefrontal frontal back to understand the degree of DNA methylation of each independent CpG site.
study, the Reagan Standard Pathology Diagnostics AD, according to the National Institute on Aging, followed by a standard autopsy.
overall, 447 participants (60.4%) met the aD pathological diagnostic criteria, confirming that DNA methylation of the sORL1, ABCA7, HLA-DRB5, SLC24A4 and BIN1 genes in the brain was associated with AD pathology.
the discrete traits of AD pathology were replaced with two quantitative molecular-specific markers (i.e., A-beta protein load and tau protein-paired screw-wire structure assembly density), the association between the two remained fairly strong.
, the degree of transcription of SORL1 and ABCA7 genes to express RNA was clearly related to the concentration density of RNA expression in pairs with tau protein, and bin1 gene expression was clearly related to The A-beta protein load.
studies have shown that the degree of methylation of DNA at multiple AD sites in the brain is associated with AD pathology.
further confirmed that the AD pathology process involved the interruption of DNA methylation.
Source: Decoding Medicine.