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Recently, neurons published online the Institute of Neuroscience of the Shanghai Institute of Life Sciences of the Chinese Academy of Sciences, the Center for Excellence and Innovation in Brain Science and Intelligent Technology of the Chinese Academy of Sciences, and the Dujulin Research Group of the National Key Laboratory of Neuroscience, entitled "The left core mediates zebrafish light preference behavior through a non-symmetrical visual path, " and was highlighted in the form of "Video Abstract".
behavior is a common instinctive behavior in the animal world, which is very important for animal survival.
the study found that the left backside nucleus mediated the zebrafish's light preference behavior through an unsympathetic visual pathway consisting of retinal nerve cells and bulging thoraum brains.
the work revealed new features of the neutrheal-mediated light preference behavior, and for the first time found a neural loop mechanism of light preference behavior in vertebrates.
is a highly conservative nuclear group in vertebrates.
mammalian studies have shown that the nucleus is the center of emotional control.
controls anxiety, fear, reward, depression, and other related behaviors by mainly accepting input from the limbic system and substrate nerve sections.
same time, a great deal of work has shown that the nucleus also accepts the input of various sensory information, but at present people are still unclear about the specific neural loop of these sensory inputs and their corresponding functions.
Image caption (left) Is inspired by a painting of the "Holtang Moon" mood in ancient Chinese poetry: in the lotus pond on the night of the moon, small fish play around the bright moon shadow.
pattern diagram of the neural loop mechanism of light preference behavior in the same area (right).
Model of retinal nerve cells projected in the fourth branch region - lon convex cymbal brain - left back side cymbal pathway: a group of retinal nerve cells with a continuous visual response projected to the bulge mound on the other side Brain, the environmental background light information is transmitted to the bulging mauling brain, and the two-sided bulging thoracic brain is biasedly projected to the left back side core, thus transmitting the ambient background light information to the left back side kernel, mediating the generation of light preference behavior.
to explore the neural function of the neutrological visual input, the researchers first tested the role of the nucleation in optical preference behavior.
normal zebrafish larvae have a clear light preference behavior, which is severely impaired by injury or functional silence on the left back side of the nucleus, rather than the right side of the larvae.
, by activating the left backside nucleus by photogenetic means, preference can be re-induced in young fish with no light preference removed from the eyes.
that the nucleation is sufficiently necessary for light preference behavior.
Second, through in-body calcium imaging and electrophysiological records of the nuclei neurons, it was found that the neurons with visual response were more distributed in the left back side of the hem, while the persistent visual response and nerve activity intensity of these neurons could encode the length and strength given by the background light of the environment respectively.
these two coding strategies, the nucleation can sense the length and strength of the background light in real time, thus mediating the light preference behavior.
Further to understand how visual information is transmitted to the nucleus, the researchers combined morphological tracing and functional experiments to find that the left back side kernel receives excited single-synapse connections from the bulging cytoblast, which in turn receives input from retinal nerve cells through its fourth projected brain region.
damage or functional silencing of the bulging brain can reduce light preference behavior, indicating that the retinal nerve cells - lon bulging cytocephalus - left back side cymbal pathway introduces light preference behavior.
, they tested the projection characteristics of this neural pathway in detail and found that most of the retinal nerve cells involved were ON-type cells; Showed a persistent and left-right symmetrical visual response, while both sides of the bulging mound brain are more projected to the left back side of the nucleus, so that the left back side of the nucleus neurons have a stronger visual response, resulting in the neural pathway left and right asymmetry.
this work extends the function of the nucleation to light preference behavior and suggests that the nucleation may act as an intermediary for sensory and emotional information to communicate with each other in the brain.
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