The loss of NK cell subgroup secretion growth factors can result in limited embryo growth.

Limited embryonic development and recurrent abortion are clinically common pregnancy-related diseases, which are closely related to the microenvironment abnormality of the mother's immune system.
Why would anyone have a repeated miscarriage? Professor Wei Haiming and Professor Tian Zhigang of the Institute of Immunology of the Chinese University of Science and Technology worked together to find that a large number of NK cell subgroups exist locally in early pregnancy metamorphosis tissue spotting in humans and mice to promote the development of embryos by secreting growth factors.
the absence of nk cells, which secrete growth factors, there is a limit to embryonic growth.
the results were published recently in The Journal of Immunization, a top journal of Cell Publishing Group.
the development of the embryo needs to form a special mother-fetal interface to protect the normal development of the fetus.
the mother-fetal interface includes a large number of metamorphosis natural killer cells (dNK), which account for 70% of the total number of lymphocytes in the first trimester of pregnancy, and it is not clear what role such a large number of dNK cells play in embryonic development.
the team compared the functional genetic differences between metamorphosis NK cells and peripheral blood NK cells through whole gene screening, and found that the high expression of PTN and OGN in early pregnancy metamorphosis was very important for early embryonic development.
the hlA-G interaction with metamorphosis NK cells expressed by the fluff-derived extra-fed layer cells from the embryo source, inducing NK cells to express growth factors in large numbers and promoting embryonic development.
found significantly less metamorphosis NK cells in patients with recurrent miscarriages to express growth factors and were unable to support the normal development of early embryos.
in order to save the limitation of embryo growth due to the reduction of NK cell secretion growth factor, the team induced metamorphosis-like NK cells in vitro with bone marrow hematopoietic stem cells, and conducted intravenous transmission treatment in mice, and improved the pregnancy outcome of aged mice and growth factor defects in mice after transmission, and impaired embryo growth.
the study found that NK cells have unique physiological functions to promote embryonic development in the metamorphosis tissue, and explored a targeted induced specific function NK cell transmission program to provide new ideas for clinical treatment of embryo growth restriction and recurrent abortion and other related diseases.
Source: Science Daily.