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Recently, the latest research results of Wang Chengshu Research Group of Shanghai Institute of Plant Physiology and Ecology of the Shanghai Institute of Life Sciences of the Chinese Academy of Sciences were published online on PLoS Pathogens under the title Ofgent LysM effectors contributing to the the virulence of Beauveria bassiana by nature by object i defenses.
study of insect pathogen fungal globulins revealed the effect mechanism of LysM protein-mediated fungus-insect interoperability.
Iftin in fungal cell wall ingredients is an important pathogen pattern molecule, plant pathogen fungus by secretion containing LysM structure of the effector to protect the cell wall, binding to free polysaccharides or competitive inhibition of host polydocytogen receptors, inhibited by pathogens polydoctin-induced host immune response.
because there is no fungus-plant exospoplast structure, animal pathogen fungi do not produce plant pathogen-like effect proteins to interfere with or inhibit the host's immunity.
Wang Chengshu research team through the analysis shows that the insect pathogen fungal spores globulin genome encodes 12 sequences and structures of different LysM proteins (named Blys1-Blys12), different protein genes in different growth conditions of different expression characteristics.
six of these genes were highly expressed when the bacteria invaded the insect's blood cavity, and the results of the targeted knockout of the six genes showed that the absence of the Blys2 and Blys5 genes significantly affected the insecticidal power of the bloc.
biochemical analysis showed that both proteins were able to bind to a few butys, which were affected by the LysM domain.
of GFP protein markers have shown that Blys2 is secreted to bind to a few butyls in the cell walls of fungi, and Blys5 protects the cell walls from the degradation of a few butyl enzymes.
compared with wild strains, the development rate of missing mutant strains decreased in the blood cavity of insects and induced insect immunity levels to increase.
interestingly, the LysM-effect protein gene Slp1, which uses the plant pathogen fungus rice pestilence bacteria, was able to complete the missing physiology of Blys2 and Blys5.
results show that the LysM protein can act as an effect molecule to mediat the interaction between fungi and insects.
the results of this research established a fungus-insect mutual recognition of the effect mechanism.
has been funded by the Chinese Academy of Sciences' Strategic Pilot B Project and the National Key Research and Development Program.
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