"The magical intermittent diet!" It can not only improve fatty liver, but also control diabetes

On October 11, 2021, Molecular Nutrition & Food Research, an international academic journal in the field of nutrition, published an article“Improvement of non-alcoholic fatty liver disease in mice by intermittent use of a fasting-mimicking diet" , the study used a mouse model to report that an intermittent diet regimen can effectively improve fatty liver
.

"Improvement of non-alcoholic fatty liver disease in mice by intermittent use of a fasting-mimicking diet" "Improvement of non-alcoholic fatty liver disease in mice by intermittent use of a fasting-mimicking diet"

 

 

With the improvement of human nutritional conditions in modern life and the increase of obese people worldwide, the incidence of non-alcoholic fatty liver disease (Non-alcoholic fatty liver disease, referred to as fatty liver) is increasing
.

For a long time, the progress of fatty liver in pharmacological treatment is very limited, and diet control and exercise are the main intervention methods at present

 

Figure: Molecular mechanism of intermittent dieting to improve fatty liver

Figure: Molecular mechanism of intermittent dieting to improve fatty liver

A doctoral student in Chen Yan's research group, Zhao Jingyu, and others used a high-fat and high-sucrose diet to establish a fatty liver model in mice, and analyzed the effect of intermittent dieting as a dietary intervention strategy on fatty liver
.

Intermittent dieting uses meal replacement products provided by Beijing Zhenbainian Biotechnology Co.
, Ltd.
, which contain lower carbohydrate and protein content, and higher dietary fiber content

High-fat and high-sucrose diet established a fatty liver model in mice, and analyzed the effect of intermittent dieting as a diet intervention strategy on fatty liver

The study shows that intermittent dieting can improve various pathological states of fatty liver, and may achieve its intervention function by increasing the degradation of adipose tissue and promoting fatty acid oxidation in the liver, providing a new idea for clinical intervention in non-alcoholic fatty liver disease
.

Researcher Chen Yan from the Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences and Lu Qi from Tongji University School of Medicine are the co-corresponding authors of the paper, and Zhao Jingyu, a doctoral student at the Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, is the first author of the paper
.

This work was funded by the National Natural Science Foundation of China and the Ministry of Science and Technology, and also supported by the public technology platform and animal platform of the Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences

Natural Science Foundation Diabetes Chen Yan Intermittent dieting is an effective nutritional intervention for diabetes Intermittent dieting is an effective nutritional intervention for diabetes Comparison of glycemic improvement between intermittent calorie restriction and continuous calorie restriction in diabetic miceComparison of glycemic improvement between intermittent calorie restriction and continuous calorie restriction in diabetic miceNutrition & Metabolism

Calorie restriction (CR), or dieting for short, is considered to be a nutritional intervention that can improve metabolism and prolong life
.

Because continuous dieting has certain difficulties in practical applications, the concept of intermittent dieting has been proposed in recent years

Calorie restriction (CR), or dieting for short, is considered to be a nutritional intervention that can improve metabolism and prolong life

Icon: Islet 4 mice immunized staining, islet β cells can be seen in type 2 diabetic mice significantly reduced, significantly increased after intermittent diet intervention
.

Icon: Islet 4 mice immunized staining, islet β cells can be seen in type 2 diabetic mice significantly reduced, significantly increased after intermittent diet intervention
.

immunity

Reference link:

Reference link:

Article link: https://doi.

org/10.
1002/mnfr.
202100381

Article link: https://doi.
org/10.
1002/mnfr.

Link to the paper: https://pubmed.
ncbi.
nlm.
nih.
gov/31485253/

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