The manufacturer of clomiphene citrate tells you some precautions

Clomiphene citrate capsule is a hormone resistant drug The mechanism of stimulating ovulation is not clear Because this product has a weak and strong antagonistic effect on estrogen, the stimulation of ovulation may be in the hypothalamus First of all, the antagonistic effect is dominant By occupying the estrogen receptor of the hypothalamus competitively, it interferes with the negative feedback of endogenous estrogen, promotes the secretion of luteinizing hormone and follicle stimulating hormone, and then stimulates the growth of the follicle, and after the follicle matures, the secretion of estrogen The amount of gonadotropin released increased, and the peak value of gonadotropin released before ovulation was stimulated by positive feedback On October 27, 2017, the list of carcinogens published by the International Cancer Research Institute of the World Health Organization was preliminarily sorted out for reference, and clomiphene citrate was included in the list of three types of carcinogens Clomiphene citrate manufacturers remind you to pay special attention to: 1 Animal experiments prove that this product can cause teratogenesis During the treatment period, the basic body temperature should be measured daily to monitor the ovulation and conception of the patient, and the drug should be stopped once pregnant 2 PCOS should be used with caution 3 During the treatment, the following tests were carried out as required: ① ovulation stimulating hormone (FSH) and luteinizing hormone (LH); ② the 24 dehydrocholesterol content in plasma was measured in long-term users to find out whether the treatment had any effect on cholesterol synthesis; ③ the content of corticosterone transfer protein in plasma; ④ the content of serum thyroxine; ⑤ the content of sex hormone binding globulin; (6) liver function test of bsp; (7) thyroxine binding globulin content (possibly increased)
4 Attention should be paid to the examination during the medication: before the beginning of each course of treatment, the size of the ovary should be correctly estimated; the basic body temperature should be measured every day, and the level of estrogen and serum progesterone should be measured if necessary; the content of pregnanediol in the urine should be measured to determine whether there is ovulation; the liver function should be measured before the treatment, and the fundus and slit lamp should be checked if the treatment is more than 1 year; if there is visual impairment in the medication, the medication should be stopped immediately Check accordingly.