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    Home > Biochemistry News > Biotechnology News > The Mass Spectrometry System team and Shanghai Jiaotong University collaborated to reveal a new regulation mechanism of schizophrenia through non-standard quantitative proteomics technology

    The Mass Spectrometry System team and Shanghai Jiaotong University collaborated to reveal a new regulation mechanism of schizophrenia through non-standard quantitative proteomics technology

    • Last Update: 2022-01-07
    • Source: Internet
    • Author: User
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    The National Protein Science Research (Shanghai) Facility Mass Spectrometry System Team of Zhangjiang Laboratory and Shanghai Jiao Tong University’s Wan Chunling Research Group jointly published an online publication titled “Leukocyte proteomic profiling in first” in the internationally renowned journal “Antioxid Redox Signal.
    ” on May 24, 2019.
    -episode schizophrenia patients: does oxidative stress play central roles in the pathophysiology network of schizophrenia?" The latest research results, this study reveals the possibility of oxidative stress in the pathophysiology of first-episode schizophrenia The important role of existence

    .
    The mass spectrometry system used high-resolution non-standard quantitative mass spectrometry detection technology to perform high-throughput proteomic quantitative analysis on nearly 30 patients and control leukocytes without removing high-abundance proteins, and a total of 4136 non-standard proteins were identified.
    Redundant proteins, of which 475 proteins have changed significantly

    .
    Further bioinformatics and functional analysis revealed the potential relationship between schizophrenia and oxidative stress and energy metabolism

    .

     


    Schizophrenia is a clinical syndrome composed of a group of symptoms

    .
    It is a multifactorial disease, mostly in young adults with slow or subacute onset, clinically often manifested as syndromes with different symptoms, involving various obstacles in perception, thinking, emotion, and behavior, as well as incoordination of mental activities

    .
    Although after years of research, the current understanding of its etiology is not very clear, and its pathophysiology is not very clear

    .
    Because schizophrenia is affected by multiple factors such as genes, development, environment, etc.
    , the study of its pathophysiology also brings great complexity, and it is difficult to conduct effective research on it through univariate molecules

    .

     


    Recently, genome research has used genome wide association studies (GWAS) to find the association between major histocompatibility complex (MHC), which confirmed the connection between the immune system and schizophrenia

    .
    The results of a recent large-scale GWAS study conducted in the Chinese population further showed the important role of energy metabolism pathways in schizophrenia

    .
    These analytical studies provide potential research directions for schizophrenia, such as immune system dysfunction or energy metabolism disorders, but it is impossible to determine the specific impact of gene mutations

    .

     


    The researchers combined advanced experimental techniques and methods to conduct a systematic non-standard quantitative proteomic analysis of the white blood cells of 20 patients with first-episode psychosis and 10 healthy people, excluding 4 patient samples with deviations from the results, and a total of 26 samples from the population 4136 non-redundant proteins were identified, 3152 proteins were identified in at least 3 samples, including 1573 shared proteins, of which 475 protein expression levels changed significantly (including 217 up-regulated and 258 down-regulated ), PCA analysis results show that the two groups of people can be clustered well

    .
    Further in-depth bioinformatics functional analysis showed that in patients' white blood cells, oxidative stress pathways and energy metabolism pathways were significantly activated, which mediated the process of cell apoptosis and induced the occurrence of mental diseases

    .
    The change trend of pyruvate levels in patients' plasma, which is closely related to energy metabolism, also confirms this result

    .

     


    This work was jointly completed by Mass Spectrometry System and Shanghai Jiaotong University Wan Chunling's research group.
    Dr.
    Jiang Jie of Wan Chunling's research group and Dr.
    Peng Chao, the head of the mass spectrometry system, are the co-first authors, and Professor Wan Chunling is the corresponding author

    .
    The research was supported by the National Key Research and Development Program, the National Natural Science Foundation of China, the Shanghai Municipal Commission of Science and Technology, the key technical personnel of the Chinese Academy of Sciences, and the Shanghai Key Laboratory of Psychiatry Open Project

    .

     

    Article link: https://  

    Figure 1: The role of oxidative stress in first-episode schizophrenia

     

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