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    Home > Biochemistry News > Biotechnology News > The mechanism by which the body's immune system fights the Ebola virus.

    The mechanism by which the body's immune system fights the Ebola virus.

    • Last Update: 2020-08-08
    • Source: Internet
    • Author: User
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    According to a recent paper published in the latest issue of the journal Plos Origin by researchers from the University of Texas School of Medicine, Vanderbilt University and the Ragon Institute, it is possible to further kill the virus by combining two types of human-derived antibodies that target different sites of the Ebola virus.
    results reveal the mechanism by which the body's immune system fights viral infections and help develop new antibody-based treatments.
    in the study, the authors extracted monoclonal antibodies from survivors of different Ebola virus infections and analyzed their respective antiviral capabilities.
    have different effects on antibodies that target the glycoprotein "hat" or viral glycoprotein base region.
    , for example, antibodies that target glycogenized hats inhibit the binding of viruses to cell surfaces, cell-to-cell transmission, and the disappointment of viral particles.
    antibody molecules targeting the base region activate NK cells and promote single-core and neutrophils to destroy infected cells.
    in summary, these findings suggest that different types of antibody molecules can function through different mechanisms and act as synergies when they exist at the same time.
    According to the authors, "cocktail" combination antibody therapy may be the future direction of related therapies.
    "The current treatment of infections with viruses such as Ebola through antibody cocktail therapy is characterized by different types of antibody targeting sites, and our researchers have shown that this different target can have different follow-up biological effects."
    thus provides evidence of the effectiveness of cocktail therapy."
    .
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