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Dali Roussia is a native plant pathogenic fungus with a wide range of hosts, causing serious yellow wilt disease in the world, causing huge economic losses to China's cotton production every year.
like most pathogenic microorganisms, the fungus relies on its secreted effect molecules (effector, or effect proteins) to overcome plant innocial immunity and thus colonized the host.
and resistant plants tend to be able to identify effect molecules, activate stronger plant immunity (effector-triggered immunity, or ETI) to inhibit the successful proliferation of pathogens.
at present, very few effect molecules that can be identified by plants and cause ETI have been found, and no effect factors have been found that can go directly into the nucleus of plant cells to regulate the immune response.
Huishan, a researcher at the Institute of Microbiology of the Chinese Academy of Sciences, has been working in recent years on the pathogenic mechanism of Dali mycobacteria and the mechanism of crop resistance to yellow wilt disease.
In the study of the small molecule exosome of Dali mycobacteria, it was found that a special effect mechanism, VdSCP7, can regulate plant immunity by transporting from the plant's outer body to the nucleus;
VdSCP7 was found in the exosome proteomics of Dali mycobacteria, which is a specific exogen protein of the genus Cylindrella.
study found that VdSCP7 encodes nuclear positioning signals that can be secreted from pathogens to cross into plant cells and locate to the nucleus (Figure A); However, the invasion of plants by pathogenic ovaries (e.g. chili mold) is accelerated; it is worth noting that the gene knock-out of mutants in VdSCP7 is significantly more pathogenic in cotton hosts (Figure B), indicating that cotton hosts may have potential resistance to gene identification VdSCP7, activation of plant immunity (Figure C).
VdSCP7 is the first nuclear positioning effect molecule to be found in mycobacteria.
this result is the result of guo Huishan's research team following the recent discovery of the active oxygen-calcium ion signaling pathrail-regulating the formation and intrusion mechanism of infested nails (Zhao et al., 2016 P. Important advances have been made in the study of the secretion and transfedal function of the PLoS Pathogens after the effect protein secretion interface (Zhou et al., PLoS Pathogens) of infested nail derivation and close contact with plant cell walls to form the Septin skeleton ring.
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