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    Home > Biochemistry News > Biotechnology News > The metabolism of biliary erythrin in the liver.

    The metabolism of biliary erythrin in the liver.

    • Last Update: 2020-10-28
    • Source: Internet
    • Author: User
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    . Name(i) Intake of biliratin by liver cellsBiliumin in blood is delivered to the liver in the form of "biliratin-albumin" and is quickly ingested by liver cells. Hepatocellulars have a strong ability to ingest bilirin in the blood. Experiments have shown that after injection of radioactive bilirubin, it takes about 18 minutes to remove 50% from the plasma. The liver's able rapid intake of bilirubin from plasma is due to the important role played by the two carrier proteins, Y protein and Z protein, in liver cells. These two carrier proteins (mainly Y proteins) can specifically bind to
    organic
    anions. When blood enters the liver, a special carrier protein on the liver cells in the Disse gap binds to biliratin, disengages it from the albumin molecule and transports it to the liver cells. Then binding with Y and Z proteins in cell fluid, the main is binding to Y protein, when Y protein binding satiety, Z protein binding only increased. This combination prevents bililin from flowing back into the blood, allowing bililin to continue to flow into the liver cells. Bilithione is bindned by carrier proteins and delivered to the endostophine in the form of "bilirin-Y protein" (bilirin-Z protein). This is an energy-consuming process and reversible. If the ability of liver cells to process bilirin decreases, or produces too much bilirin, which exceeds the ability of liver cells to process bilirin, bilium erythrin, which has entered liver cells, can also flow back into the blood, increasing bilibin levels in the blood.
    Figure 11-11 The production of glucoalic acid bilirubin Y protein is an alkaline protein consisting of two sub-bases with a molecular weight of 22,000 and 27.000, accounting for about 5% of the total amount of
    proteins
    in hepatocellular fluid. It is also an induced protein, and phenybabito induces the synthesis of the Y protein. Competitive binding of Y proteins, such as thyroxine, sodium bromofluate (BSP) and indigo (ICG), affects the transport of biliuretin. Y protein can bind to the above-mentioned substances, so it is also known as "ligation binding protein" (ligadin). Because the newborn Y protein reaches normal adult level after 7 weeks of birth, it is easy to produce physiological neonatal non-hemolysal jaundice, clinically available for phenytobibido treatment.. Z protein is an acidic protein with a molecular weight of 12,000 and affinity with bililine less than Y protein. When biliratin concentrations are low, bilium is preferred to bind to the Y protein. At high bilithion concentrations, the binding of Z protein to bilirin increases.(ii)
    -transformation of liver cells to bilirubin
    effect there is bilirubin-urea diphosphate glucagonic acid
    transferase
    (bilirutin-UDp glucuronyl transferase, BR-UDPGA-T), which catalytic bilirubin and glucosalic acid binding to glucates. Since two propylene acid-based carboxyls in bilirubin molecules can be combined with hydroxyl hydroxyl on glucose acid C1, two bindings can be formed, namely bilirubin glucosalic acid-ester and bilirubin glucosaldehyde deester (Figure 11-11). In human bile, the binding of bilirubin mainly bilirubin glucosalate diesters (70-80%), followed by bilirubin glucosalic acid - (20-30%), but also a small part with sulfate root, methyl, acetyl, glycine and so on.bilirubin after the above conversion is called the binding bilirubin, combined with bilirubin is less soluble than bilirubin fat and water-soluble enhancement, and plasma albumin affinity is reduced, so easy to discharge from the bile, but also easy to excrete from the urine through the kidney gloter. However, it is not easy to pass through the cell membrane and blood-brain barrier, so it is not easy to cause
    tissue
    poisoning, is an important way to detoxify bililine.(iii) Excretion of the liver on bilirubin bilirubin is combined and transformed in the endoblast, and is transported and discharged into the capillary bile tube after binding and conversion in the plasma by the Golki complex, lysosomes, etc. The concentration of bililin binding in the capillary bile tube is much higher than the intracular concentration, so bilium is discharged from the liver is an energy consumption process of the reverse concentration gradient, and it is also a weak link of the liver's treatment of bilium erythrin, which is easily damaged. If the excretion process occurs obstacles, the combination of bilirubin can be returned to the blood, so that the blood binding bilirubin levels increased.saccharide cortide
    rogen
    can not only induce the production of glucoalic acid transfer enzyme, promote bilirubin and glycoalic acid binding, but also promote the discharge of binding bilirubin. Therefore, such hormones can be used to treat high bililinemia.the liver's intake, transformation, and excretion of bilirin visible graphs 11-12.11-12 Metabolism Map of Biliorene in Hepatocells shows

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