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【Chemical Machinery Equipment Network Hot Concern ] When coughing or sneezing, the human body produces droplets and droplet nuclei and other complex components that mix with the air to produce aerosols.
This aerosol is closely related to the physiological state of the human body.
The analysis of VOCs, proteins, fatty acids and bacteria in it can even be used for the identification of certain diseases.
For example, studies have shown that increased emissions of acetaldehyde and propionaldehyde in exhaled air can reflect Streptococcus pyogenes infection, and n-propyl acetate is related to influenza A virus (IAV).
Hot attention of Chemical Machinery Equipment NetworkChemical machinery and equipmentThis aerosol is closely related to the physiological state of the human body.
The analysis of VOCs, proteins, fatty acids and bacteria in it can even be used for the identification of certain diseases.
For example, studies have shown that increased emissions of acetaldehyde and propionaldehyde in exhaled air can reflect Streptococcus pyogenes infection, and n-propyl acetate is related to influenza A virus (IAV).
In addition to more intense respiratory symptoms such as coughing and sneezing, aerosols can also be produced during normal breathing and speaking.
Although the aerosol exhaled by the human body is produced at any time, it is very difficult to detect it.
This is because the content of standards in aerosols is often very low, and there are complex interference components.
At present, the detection of exhaled aerosol generally requires the use of gas bags or cylinders to collect enough samples to detect trace markers in mass spectrometry.
Sample collection requires active air blowing and professional assistance.
The process is complicated and time-consuming, and it is impossible to achieve daily screening and diagnosis of large quantities of exhaled aerosols.
Although the aerosol exhaled by the human body is produced at any time, it is very difficult to detect it.
This is because the content of standards in aerosols is often very low, and there are complex interference components.
At present, the detection of exhaled aerosol generally requires the use of gas bags or cylinders to collect enough samples to detect trace markers in mass spectrometry.
Sample collection requires active air blowing and professional assistance.
The process is complicated and time-consuming, and it is impossible to achieve daily screening and diagnosis of large quantities of exhaled aerosols.
Researchers at Jinan University took inspiration from the role of masks in blocking the inhalation of harmful substances and the spread of droplets, and developed a mask micro-extraction technology that inserts a solid-phase micro-extraction probe into the mask.
The mask is used to achieve exhaled aerosol in daily life.
Collection and enrichment.
When wearing a mask, the filter layer in the middle of the mask can effectively isolate biological aerosols, which is equivalent to collecting aerosols exhaled by the human body in the filter layer, and the collection effect is good.
In addition, carrying a mask does not affect daily life, and samples can be collected for a long time to ensure the enrichment of trace markers.
The mask is used to achieve exhaled aerosol in daily life.
Collection and enrichment.
When wearing a mask, the filter layer in the middle of the mask can effectively isolate biological aerosols, which is equivalent to collecting aerosols exhaled by the human body in the filter layer, and the collection effect is good.
In addition, carrying a mask does not affect daily life, and samples can be collected for a long time to ensure the enrichment of trace markers.
To verify the new method, the researchers first tested the mask micro-extraction mass spectrometry, compared the background signal and the fingerprint spectrum of the exhaled aerosol, and examined the exhaled aerosol after chewing gum, eating bananas and garlic, and successfully exhaled the aerosol.
Volatile markers such as cooling agents in chewing gum, butyl butyrate in bananas, and volatile sulfides in garlic were detected in the sol.
In addition, it also has good results for the detection of human metabolites such as nicotine and its metabolite cotinine.
In addition to volatile organic compounds, the study also found that semi-volatile and hardly volatile substances can also be detected by mask micro-extraction mass spectrometry, such as oral mouthwashes and hardly volatile pharmaceutical ingredients in medicines.
Volatile markers such as cooling agents in chewing gum, butyl butyrate in bananas, and volatile sulfides in garlic were detected in the sol.
In addition, it also has good results for the detection of human metabolites such as nicotine and its metabolite cotinine.
In addition to volatile organic compounds, the study also found that semi-volatile and hardly volatile substances can also be detected by mask micro-extraction mass spectrometry, such as oral mouthwashes and hardly volatile pharmaceutical ingredients in medicines.
At present, mass spectrometry-based breath analysis technology is relatively mature.
GC-MS technology, LC-MS technology, and soft ionization technologies such as electrospray and matrix-assisted laser analysis have all been widely used in related research.
However, the problem of sample collection has always restricted the application of aerosol analysis.
Mask micro-extraction not only makes sample collection convenient, it can be used for mass detection, but it can also be separated from the mass spectrometry analysis process in time and space, and can reduce the biological hazards such as clinical exhaled aerosol samples of infectious viruses.
The risk of samples has greatly expanded the application prospects of aerosol analysis technology for clinical analysis and disease diagnosis of nose, nose and respiratory diseases.
GC-MS technology, LC-MS technology, and soft ionization technologies such as electrospray and matrix-assisted laser analysis have all been widely used in related research.
However, the problem of sample collection has always restricted the application of aerosol analysis.
Mask micro-extraction not only makes sample collection convenient, it can be used for mass detection, but it can also be separated from the mass spectrometry analysis process in time and space, and can reduce the biological hazards such as clinical exhaled aerosol samples of infectious viruses.
The risk of samples has greatly expanded the application prospects of aerosol analysis technology for clinical analysis and disease diagnosis of nose, nose and respiratory diseases.
Original title: Realizing mass spectrometry analysis and micro-extraction masks can still be used like this
