The molecular characteristics of liver metastasis in pancreatic cancer were deciphered

Eighty percent of pancreatic cancer patients end up with tumor metastasis.
the U.S. National Comprehensive Cancer Network guidelines do not recommend surgical treatment for patients with metastatic pancreatic cancer.
and chemotherapy was very limited, with a medium survival of only 6.9 months, which led to a stalemate in research related to the diagnosis and treatment of pancreatic cancer.
, most studies of pancreatic cancer metastasis are based on cell lineages, mouse models, puncture samples, or autopsy samples.
these samples helped to explore the molecular mechanisms of pancreatic cancer metastasis, the information provided was limited, especially in the analysis of the characteristics of the transfer cooker transcription group.
metastatic pancreatic cancer accounts for more than half of all pancreatic cancers.
The prior clinical practice of Sun Yongwei's team confirmed that for patients with highly selected liver oligarch metastatic pancreatic cancer with primary tumors located at the tail of the pancreas, the same-term surgery of primary and metastatic lesions can significantly benefit the survival of patients, with a median survival of up to 16.8 months.
these clinical practices, the team from the Shanghai Institute of Nutrition and Health of the Chinese Academy of Sciences worked with the team at Renji Hospital in Shanghai.
study, researchers deciphered the heterogeneity of the liver metastasis and primary lesions of pancreatic cancer, confirming that the metastasis of pancreatic cancer is a multi-stage, multi-step process.
interaction and mutual adaptation between tumor cells and tumors promotes the growth of pancreatic cancer cells in the liver.
early stages, mutations in the KRAS gene in pancreatic cancer cells promoted the spread of tumor cells from the primary lesions.
however, after blood circulation and distant planting, its main task became how to survive, how to further grow and multiply, become a "qualified" plant stove.
implantation of the liver, the spreading tumor cells regained their skin esopid ideosis, while their energy metabolism was reshaped to obtain stronger phosphate phosphate, phosphate glycosaccharide pathping and aerobic sugar enzymes.
these provide the necessary basis for the growth of tumor cells.
(Reporter Hu Derong)