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    Home > Active Ingredient News > Study of Nervous System > The molecular mechanism of saikosaponin-d causing damage to hippocampal neurogenesis|CTM Hot Research

    The molecular mechanism of saikosaponin-d causing damage to hippocampal neurogenesis|CTM Hot Research

    • Last Update: 2021-04-14
    • Source: Internet
    • Author: User
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    Neural stem/progenitor cells (NPCs) are self-renewing pluripotent stem cells in the central nervous system (CNS).

    NPCs can differentiate into neurons or glial cells to provide a sufficient number of brain cells.

    Neurogenesis is a very complex process, in which NPCs undergo proliferation, differentiate into neurons, migrate and integrate into the functional brain neural network.

    Some people think that there are two neurogenesis areas in the adult mammalian brain, and the dentate gyrus (DG) of the hippocampus is one of them.

    The neurogenesis of adult hippocampus is very interesting, because this area is related to the occurrence of various CNS diseases.

    Some people think that when the hippocampus is pathologically stimulated, the neurogenesis of the hippocampus will be affected, leading to the occurrence of neurological diseases.

    Although there is still controversy about the extent of adult hippocampal neurogenesis and its relevance to diseases, more and more evidence shows that neurogenesis persists in adult rodents and is closely related to cognitive function.

    Neurotrophic factors and their receptors are expressed at a high level in the hippocampus, and are key factors to maintain synaptic plasticity and promote the survival and differentiation of the nervous system.

    At present, studies have shown that multiple neurotrophic factors are related to the neurogenesis of NPCs.

    The team of Professor Shiping Ma from Nanjing China Pharmaceutical University recently published the latest research results "Saikosaponin-d impedes hippocampal neurogenesis and causes cognitive deficits by inhibiting the survival of neural stem/progenitor cells via neurotrophin receptor signaling in mice" in Clinical and Translational Medicine.
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