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N6-methyladenosine (m6A) is one of the most abundant mRNA modifications that plays an important role in RNA metabolism and function.
had discovered that the RNA virus genome contained m6A modification searly 40 years ago, but its function was unknown, and until recently studies had reported that m6A modification affected HIV, hepatitis B and Zika virus infection and replication.
there is little research on viral m6A modification and function and the molecular mechanism is unclear.
recently, Guan Wuxiang and Deng Fei, researchers at the Wuhan Institute of Viruses of the Chinese Academy of Sciences, made progress in regulating virus replication with enterovirus type 71 (EV71) m6A modification.
studies have shown that EV71 RNA contains m6A modification in VP, 2C, 3D and other protein coding regions;
, the study found that methylaterase METTL3 interacts with EV71 RNA-dependent RNA polymerase (RNA-RNA polymerase, RdRp) 3D and promotes viral replication by increasing 3D SUMO/ubinomodification levels.
this study not only reveals the molecular mechanism of m6A modification affecting virus replication, but also provides new targets and ideas for the prevention and treatment of viruses.
research paper "N6-methyladenosine and METTL3 modulatovirus 71 reproducing" (m6A modification and METTL3 regulatory EV71 replication) was recently published in Nucleic Acids Research .)
doctoral student Yan Haojie is the first author of the thesis, Guan Wuxiang and Deng Fei are the authors of the paper.
the research was supported by the National Key Research and Development Program, the Key Deployment Project of the Chinese Academy of Sciences, and the Opening Of the Key Laboratory of High pathogenic Stenod Biology and Biosecurity of the Chinese Academy of Sciences.
Source: Wuhan Virus Research Institute.