The most continuous assembly of the human genome to date has been completed

Genomics research published online on the 29th in the British
magazine: a team of British scientists used a pocket-sized nano-hole sequencing device to assemble the human genome from the beginning, the most continuous human genome assembly to date, and only a single sequencing technology. The study also successfully analyzed areas of the human genome that were not analyzed by the most advanced sequencing methods in the past.
understanding and interpreting the human genome is the cornerstone of modern medicine, and it has been hoped that as many genomes as possible will be sequenced. Prior to this, this work was daunting due to a variety of factors, including limited speed, cost and sequencing systems. Although sequencing techniques have improved, it is challenging to assemble the human genome quickly and cost-effectively and to ensure high accuracy and integrity.
this time, researchers Matthew Luthor, Nicholas Roman and their colleagues at the University of Nottingham in the United Kingdom used a portable bio-nanoporous sequencer to sequence and assemble the genome of the human GM12878 cell line, generating 91.2gb of sequence data. Using this method, a single reading length can be up to 882kb, enabling the research team to successfully analyze the "blind spots" that previously could not be analyzed by the most advanced sequencing methods.
regrets the presence of unexerced areas in the genome, and sequencing unsequenced regions is the latest frontier in human genetics and genomics. The team said the new method could significantly improve the accuracy of structural variations and overt genetic modifications in the genome, filling 12 gaps in the human reference genome GRCh38. (Source: Science and Technology Daily Zhang Mengran)